Bruce BeutlerPublications of Bruce Beutler, 2011 Nobel Laureate in Physiology or Medicine, in The Journal of Immunology:


RNA and Imidazoquinolines Are Sensed by Distinct TLR7/8 Ectodomain Sites Resulting in Functionally Disparate Signaling Events
Elif Colak, Alasdair Leslie, Kieran Zausmer, Elham Khatamzas, Andriy V. Kubarenko, Tica Pichulik, Sascha N. Klimosch, Alice Mayer, Owen Siggs, Andreas Hector, Roman Fischer, Benedikt Klesser, Anna Rautanen, Martin Frank, Adrian V. S. Hill, Bénédicte Manoury, Bruce Beutler, Dominik Hartl, Alison Simmons, and Alexander N. R. Weber
J Immunol 2014 192:5963-5973; doi:10.4049/jimmunol.1303058

Role of Nucleic Acid-Sensing TLRs in Diverse Autoantibody Specificities and Anti-Nuclear Antibody-Producing B Cells
Yi Ting Koh, John C. Scatizzi, Jennifer D. Gahan, Brian R. Lawson, Roberto Baccala, K. Michael Pollard, Bruce A. Beutler, Argyrios N. Theofilopoulos, and Dwight H. Kono
J Immunol 190:4982-4990; doi:10.4049/jimmunol.1202986

A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding
Carlo Iavarone, Katrin Ramsauer, Andriy V. Kubarenko, Jason C. Debasitis, Igor Leykin, Alexander N. R. Weber, Owen M. Siggs, Bruce Beutler, Pu Zhang, Gillis Otten, Ugo D'Oro, Nicholas M. Valiante, M. Lamine Mbow, and Alberto Visintin
J Immunol 2011 186:4213-4222, doi:10.4049/jimmunol.1003585

Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency
Gerhard Wingender, Philippe Krebs, Bruce Beutler, and Mitchell Kronenberg
J Immunol 2010 185:2721-2729; doi:10.4049/jimmunol.1001018

Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-Dependent Wasting Disease and Intestinal Inflammation in Gimap5-Deficient Mice
Michael J. Barnes, Halil Aksoylar, Philippe Krebs, Tristan Bourdeau, Carrie N. Arnold, Yu Xia, Kevin Khovananth, Isaac Engel, Sosathya Sovath, Kristin Lampe, Eleana Laws, Amy Saunders, Geoffrey W. Butcher, Mitchell Kronenberg, Kris Steinbrecher, David Hildeman, H. Leighton Grimes, Bruce Beutler, and Kasper Hoebe
J Immunol 2010 184:3743-3754; doi:10.4049/jimmunol.0903164

The Tpl2 Mutation Sluggish Impairs Type I IFN Production and Increases Susceptibility to Group B Streptococcal Disease
Nengming Xiao, Celine Eidenschenk, Philippe Krebs, Katharina Brandl, Amanda L. Blasius, Yu Xia, Kevin Khovananth, Nora G. Smart, and Bruce Beutler
J Immunol 2009 183:7975-7983; doi:10.4049/jimmunol.0902718

Cutting Edge: Priming of NK Cells by IL-18
Julie Chaix, Marlowe S. Tessmer, Kasper Hoebe, Nicolas Fuséri, Bernhard Ryffel, Marc Dalod, Lena Alexopoulou, Bruce Beutler, Laurent Brossay, Eric Vivier, and Thierry Walzer
J Immunol 2008 181:1627-1631; doi:10.4049/jimmunol.181.3.1627

PanR1, a Dominant Negative Missense Allele of the Gene Encoding TNF-α (Tnf), Does Not Impair Lymphoid Development
Sophie Rutschmann, Kasper Hoebe, Jonathan Zalevsky, Xin Du, Navjiwan Mann, Bassil I. Dahiyat, Paul Steed, and Bruce Beutler
J Immunol 2006 176:7525-7532; doi:10.4049/jimmunol.176.12.7525

The MyD88-Dependent, but Not the MyD88-Independent, Pathway of TLR4 Signaling Is Important in Clearing Nontypeable Haemophilus influenzae from the Mouse Lung
Catharina W. Wieland, Sandrine Florquin, Nico A. Maris, Kasper Hoebe, Bruce Beutler, Kiyoshi Takeda, Shizuo Akira, and Tom van der Poll
J Immunol 2005 175:6042-6049; doi:10.4049/jimmunol.175.9.6042

Enhanced Antibacterial Potential in UBP43-Deficient Mice against Salmonella typhimurium Infection by Up-Regulating Type I IFN Signaling
Keun Il Kim, Oxana A. Malakhova, Kasper Hoebe, Ming Yan, Bruce Beutler, and Dong-Er Zhang
J Immunol 2005 175:847-854; doi:10.4049/jimmunol.175.2.847

Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules
Nicolas Anfossi, Scott H. Robbins, Sophie Ugolini, Philippe Georgel, Kasper Hoebe, Cécile Bouneaud, Catherine Ronet, Arthur Kaser, Catherine B. DiCioccio, Elena Tomasello, Richard S. Blumberg, Bruce Beutler, Steven L. Reiner, Lena Alexopoulou, Olivier Lantz, David H. Raulet, Laurent Brossay, and Eric Vivier
J Immunol 2004 173:3773-3782; doi:10.4049/jimmunol.173.6.3773

Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family
M Mohamadzadeh, A N Poltorak, P R Bergstressor, B Beutler, and A Takashima
J Immunol 1996 156:3102-6

Expression of a TNF inhibitor in transgenic mice.
K Peppel, A Poltorak, I Melhado, F Jirik, and B Beutler
J Immunol 1993 151:5699-703

Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct
J D Radolf, M V Norgard, M E Brandt, R D Isaacs, P A Thompson, and B Beutler
J Immunol 1991 147:1968-74

Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions
J Han, G Huez, and B Beutler
J Immunol 1991 146:1843-8

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo
B A Beutler, I W Milsark, and A Cerami
J Immunol 1985 135:3972-7

Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells
B A Beutler and A Cerami
J Immunol 1985 135:3969-71

Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells
J R Mahoney, Jr, B A Beutler, N Le Trang, W Vine, Y Ikeda, M Kawakami, and A Cerami
J Immunol 1985 134:1673-5

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