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The Flow Cytometry Core at SUNY Upstate Medical University is seeking a full time flow cytometry operator to work in our busy flow cytometry core facility. The successful candidate will be responsible for operation and maintenance of a BD FACS ARIA high-speed cell sorter as well as maintenance of a four-laser BD LSR II and a three-laser BD LSRFortessa. Other responsibilities include: troubleshooting flow cytometer instrumentation and software issues, multi-laser flow cytometer applications, experience handling and sorting sterile cell cultures, and data analysis using various software programs.

 

Responsibilities:

- Independently operates multi-laser, high speed cell sorter

- Responsible for routine maintenance of all equipment to ensure proper working condition

- Responsible for reviewing literature in order to keep up-to-date with current applications

- Trains staff to operate BD LSR II and BD LSRFortessa

- Responsible for testing reagents

 

Technical Skills: Knowledge of FACS principles as well as past experience operating FACS instrumentation, ability and comfort with troubleshooting instrumentation, past experience using FACS analysis software, and experience performing sterile sorts. Experience with BD flow cytometers preferred.

 

Core Competencies: Ability to work alone or in a team environment, comfortable working with instrumentation, ability to learn new principles quickly, possess strong analytical skills, must possess strong interpersonal skills.

 

Experience: A B.S. or M.S. in science with two or more years of experience in flow cytometry, and experience with BD flow cytometers is strongly preferred. Excellent computer, communication, and organizational skills are necessary.

 

Apply online to job # 029522 via the SUNY Upstate Human Resources website jobs.upstate.edu/. SUNY Upstate Medical University is an AA/EO employer engaging excellence through diversity.  Women and minorities are encouraged to apply.

Posted: September 2, 2010

  
 
 

Scientific Program Manager, Immune Therapies

JDRF Executive Office, New York, NY

Juvenile Diabetes Research Foundation International (JDRF) is currently seeking a Scientific Program Manager, Immune Therapies to join our Research team in New York City. 

JDRF is the worldwide leader for research to cure type 1 diabetes.  It sets the global agenda for diabetes research, and is the largest charitable funder and advocate of diabetes science worldwide.  The mission of JDRF is to find a cure for diabetes and its complications through the support of research.  Type 1 diabetes is an autoimmune disease that strikes children and adults suddenly, and can be fatal or lead to devastating complications.  Since its founding in 1970 by parents of children with type 1 diabetes, JDRF has awarded more than $1.4 billion to diabetes research, including $101 million in FY2009.  In FY2009, JDRF funded research projects in 22 countries throughout the world, including more than 40 human clinical trials.

The Scientific Program Manager (SPM) will assist in the management of the research projects within JDRF’s Immune Therapies Program. The SPM will build on his/her scientific experience to develop and implement research programs aimed at addressing key scientific and programmatic gaps within the Immune Therapies portfolio. S/he will liaise with both the scientific and lay communities in the management of program activities and will coordinate committees and meetings.

 

Specific responsibilities include: 

  • Plan/oversee the review of grant applications. Prepare summary statements and monitor budgets. Accountable for implementing the budgetary recommendations and any scientific contingencies of the review committee.

  • Monitor and evaluate ongoing managed research grants, collaborative academic and industry grants. Assess progress reports and evaluate the achievement of project milestones. Convene external evaluation meetings where necessary.

  • Plan, schedule, prioritize, and monitor all activities related to individual projects under the SPM’s responsibility.  Develop timelines and budgets, and ensure that tasks are completed on time and within budget.

  • Assist in the development and implementation of gap-filling research projects within the area of T1D immunotherapy.

  • Communicate with researchers to provide information about the application and review processes as well as any other pertinent matters.

  • Liaise with researchers (from academia and industry), funding agencies, and JDRF’s lay community. Represent JDRF with various organizations to exchange information, develop collaborations, and address challenges of mutual interest where appropriate.

  • Participate in and organize meetings. Develop and deliver presentations as required, and provide input and suggestions.

  • Attend relevant scientific conferences.

  • Keep in the front of scientific progress in the field of immunology of T1D.

  • Ensure that the confidentiality and security of all information under his/her supervision is maintained.

  • Operate with great latitude for independent judgment and initiative.

Experience Required

  • Ph.D. or M.D.

  • Minimum of 2 years post-doctoral or medical training experience

  • Knowledge of immunology

  • Knowledge of Type 1 Diabetes or autoimmunity strongly desired

  • Excellent oral and written communication skills

  • Strong computer skills (MS Office and internet) 

Other Requirements

  • Ability to travel about 20% of the time

  • Effectively multi-task, establish priorities, and work in a fast paced environment. Highly efficient in time management and can meet deadlines under pressure.

  • Detail-oriented and strong organizational skills.

  • Team player that has the ability to interface with all staff and volunteers. Must develop, maintain, and utilize relationships.

  • Superior active listening, observation, analytical, and problem recognition and solving skills.

  • Ability to work and make judgments independently and take initiative.

  • Excellent written, oral, and communication skills. Aptitude for presentation delivery, conveying ideas, and instructing effectively. Ability to communicate with scientific peers and the public.

JDRF offers competitive salaries and a full array of benefits including paid time off (vacation, holiday and sick), medical and dental insurance, flexible spending accounts (FSA), a maternity benefit program, and a retirement plan as well as a business casual work environment.

 

To apply for this position, please send resume with salary requirements to jobs@JDRF.org with “SPMI” only in the subject line.

 

We thank all candidates for the responses to this advertisement. However, we regret that we will be able to contact only select candidates.

 

JDRF is an Equal Opportunity Employer.

Posted: July 27, 2010

  
 
 

Associate Scientist - Oncology
Memphis, TN

St. Jude Children's Research Hospital, located in Memphis, Tennessee, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital's mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research.

Currently, St. Jude Children's Research Hospital has an opening for a Associate Scientist (Job Number 18726).

The Associate Scientist in the Oncology Department utilizes unique, advanced skills that assist investigators in achieving the highest research goals. Our laboratory is involved in translational studies emphasizing hematopoietic progenitor differentiation to improving the outcomes of patient undergoing hematopoietic stem cell transplant (HSCT) using UC blood (UCB). Currently we have three major areas of interest: Understanding the unique immune interactions involved in cord blood transplantation, ex-vivo expansion of pluripotent hematopoietic stem cells using the Notch signaling pathway, and ex-vivo manipulation of cord blood progenitors to improve engraftment.

Requirements:

  • A Bachelor's Degree in an appropriate scientific field and 15 years (post-degree) of relevant and productive work experience.

OR

  • A Master's Degree in an appropriate scientific field and 14 years (post-degree) of relevant and productive work experience.

OR

  • A PhD in an appropriate scientific field and 9 years (post-degree) of relevant and productive work experience.

Preferred skills:

  • Experience with cell culture, flow cytometry, molecular biology, and working with in vivo models is highly desired.

  • Background in Immunology is preferred.

St. Jude offers a positive working culture, professional advancement, & competitive compensation. Qualified applicants may apply for this position or others via our online process at www.stjude.org/jobs

St. Jude is an Equal Opportunity Employer and a Drug-Free Workplace.

Candidates receiving offers of employment will be subject to pre-employment drug testing and background checks.

www.stjude.org
 

Posted: July 23, 2010

  
 
 

Research Assistant Professor / Senior Research Associate

Cytometry and Microscopy Facility

 

Indiana University School of Medicine-South Bend (IUSM-SB) invites applications for a Research Assistant Professor / Senior Research Associate to manage, operate and maintain a new Cytometry and Microscopy Facility (CMF).  The CMF currently houses a Zeiss 710 confocal LSM, an Olympus FV1000 confocal and multi-photon excitation LSM, a Beckman Coulter FC 500 flow cytometer and a BD FACS Aria III cell sorter.  Responsibilities will include overseeing policy and recharge for core equipment, processing samples for users, training users to operate equipment, occasional teaching of workshops to user community, and maintaining equipment. Advanced training will be made available for either laser scanning microscopy or flow cytometry, depending on the candidates needs.  A successful candidate will have a Ph.D. in the biomedical sciences (or related field) and experience in laser scanning microscopy or flow cytometry. A candidate with publications demonstrating ability to acquire and analyze flow cytometry or fluorescence microscopy data is strongly preferred.  Candidates will be considered for Research Assistant Professor whereby the opportunity to develop an independent research plan will be available.  Candidates with a M.S. and extensive experience with either flow cytometry or laser scanning microscopy will be considered at the Senior Research Associate level. Additional information on IUSM-SB can be found at http://medicine.iu.edu.

 

Qualified individuals should send their curriculum vitae, the names and address of three references and research interests to:  Chair, Cytometry and Microscopy Search Committee, Indiana University School of Medicine-South Bend, South Bend, IN 46617 or e-mail: navari.1@nd.edu.


Posted: June 24, 2010

  
 
 

Immunology Research Scientist


The National Institutes of Health is seeking a qualified individual to head an Immunology Assay Unit. This is a full-time opportunity with Medical Science and Computing, Inc., and it is on-site at NIH in Bethesda/Rockville, MD.

 

The person who will successfully fill this position will have a deep interest in developing GLP standard immunology assays with several years experience in an industry setting (pharma/biotech). 

 

The primary duty of this unit is to develop, perform, and standardize immunology assays to support malaria vaccine development and evaluation. These assays include ELISA, and Luminex assays, parasite binding inhibition assays and parasite growth inhibition assays, cytokine evaluation by T-cell ELISPOT and intracellular staining, and membrane feeding assays to evaluate vaccines designed to block malaria transmission by mosquitoes.

 

Duties and Responsibilities

The position requires an individual with experience developing and standardizing laboratory techniques to measure immune responses of animals and humans.

  • The research scientist will introduce new equipment or new technologies to facilitate high-throughput assays.

  • He/she will explore immunostimulants and strategies for activating innate immune responses to malarial antigens in order to enhance adaptive immune responses.

  • The research scientist will characterize and compare cellular and humoral immune responses to specific malarial antigens in naïve U.S. subjects and in malaria-infected individuals in Africa, especially among vulnerable populations such as children and pregnant women.

  • The research scientist will use the assay development knowledge described above to create novel techniques, formally validate and standardize these techniques, and create standard operating procedures (SOPs).

  • The research scientist will train staff on these SOPs and will ensure that documentation practices adhere closely to GLP and GCP standards, including responsibility for documentation management, deviation reporting and auditing. This will include training plans, instructional documents, forms, competency assessments, evaluations and certifications consistent with a GLP framework.

  • The research scientist will also be responsible for laboratory safety, materials and study sample management.

Position Requirements

  • The person who will successfully fill this position will have a deep interest in developing GLP standard immunology assays, ideally with several years experience in an industry setting (pharma/biotech). 

  • They will hold a Ph.D. or an M.D. with scientific training in a relevant field, such as immunology, infectious disease, parasitology, vaccinology, or others. Experience in malaria immunology, vaccine development and evaluation is a plus.

  • Successful candidate will require in-depth understanding of the mechanisms of innate and adaptive immune responses and possible ways of increasing responses to vaccines; capacity of leading, inspiring, and supervising a group of talented technical staff for assay performance, development, and standardization. 

  • Hands-on experience with cellular assays is required.

  • Scientist will have experience in human clinical trials and GCP, GLP regulated environments. Familiarity with CLIA and CAAP clinical safety laboratories would be advantageous.

  • Ideal candidate should have experience with project management in a fast-paced, deadline-driven environment, with excellent communication and interpersonal skills.

  • The position will require substantial computer and software proficiency. Required Microsoft applications include Word, Excel, Powerpoint, Access, Visio, Project Manager, and SharePoint platforms.

  • Experience in statistical analysis software such as SPSS, SAS, JMP, or other analysis and graphing programs is desired.   

  • Experience and competency managing LIMS would be advantageous. 

  • The successful candidate must have comfort and ability to investigate and learn new equipment software interfaces and analysis programs used for scientific research and temperature monitoring.

For immediate consideration, respond with a copy of your resume and a cover letter / summary that explains your industry (biotech/pharma) experience which indicates your deep familiarity with industry standards and practices for development and implementation of immunological assays supporting product development. Send to Margaret Hishmeh at www.careers@mscweb.com

 

Posted: June 8, 2010

  
 
 

Ph.D. Scientist, Immunologist, Hospira, Inc.

 

The Ph.D. Immunologist is responsible for design, execution, and oversight of the non-clinical and clinical immunogenicity program supporting Global Biologics R&D efforts in launching biosimilar products and will be the technical leader for all immunological based assays and technologies.  This person will be responsible for managing CRO relationships and understanding evolving regulatory requirements necessary to gain timely regulatory approvals for Hospira’s biotherapeutic protein targets.  This position requires a good understanding of biologic product development.

·  Direct experience with a range of methodologies for assessing immunogenicity in animals and humans is required.  These assays will include ECL, RIP, ELISA, SPR/Biacore, and cell-based Nab assays. Must be able to assess the impact of an immunological response on PK/PD and adverse events.

·  Will handle complex and difficult assessments independently with a high level of technical skill.

· Will understand theoretical and technical aspects of entire projects.  When required, will conduct experimentation within area of expertise in an independent fashion with capability to determine relevancy and accuracy of the data.  Expected to identify technological needs for group and take lead in acquiring these technologies for Hospira.  

·  Will support of diligence efforts for biosimilar programs, and will represent R&D as a core team member on programs with strong biology emphasis. 

 

A Ph.D. degree in Immunology (or closely related field) with 6+ years experience is required. Position requires prior experience in conducting immunogenicity assessments.  Prior experience in a CRO or managing CRO relationships is a plus.

 

Application Time Table—Open until filled.

 

Contact:

Julie Helland

275 N. Field Drive

Lake Forest, IL 60045

Email: Julie.helland@hospira.com 

www.hospira.com  (Job ID: 6297BR)

 

Company Description:

Hospira's vision guides everything the company does. "Advancing" focuses on Hospira's progressive, positive and purposeful approach as it looks to the future. "Wellness" demonstrates a broad commitment to healthcare, supported by a wide variety of products that help improve the well being of patients around the world. Wellness also refers to the overall well being of Hospira's customers, employees, shareholders and communities. The "right people" — Hospira's employees — are a talented group of dedicated, customer-focused, entrepreneurial individuals who are committed to working under the highest standards of integrity and ethics. Hospira's broad portfolio of products — the "right products" — provides quality, reliability and cost-effectiveness.

 

Posted: June 1, 2010

  
 
 

Boehringer Ingelheim
Scientist IV, Immunology and Inflammation

Type: Full Time
Duration: Permanent
Education: Four-Year Degree
Experience: 5-10 Years
Location: Ridgefield, Connecticut, USA, 06877

Boehringer Ingelheim is currently seeking a highly motivated and experienced bench Scientist to join our Immunology and Inflammation Department located at our US headquarters in Ridgefield, CT. The successful candidate will be responsible for the development of molecular and cellular assays, compound profiling and target validation activities in support of drug discovery projects. In this role you will actively participate in a multidisciplinary group focused on the discovery and development of novel therapeutics with the potential to have a positive impact on patient's lives.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers.  Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success.

We realize that our strength and competitive advantage lie with our people.  We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Responsibilities:

-Independently develop and implement molecular and cellular assays useful for the identification and characterization of small molecule and NBE candidates.
-Analyze data, perform statistical analyses, document results, maintain laboratory notebook according to BIPI guidelines.
-Communicate results in written and oral presentations. Write protocols, procedures and technical reports.
-Keep abreast of literature in field; attend scientific meetings; help train junior colleagues; contribute to continuous improvement within the group.
-Comply with FDA, EPA and OSHA regulations, performing all work in a safe manner.  Maintain proper records in accordance with all SOP's and policies.
-Support and embrace diversity as an employee and representative of BIPI.

Qualifications:

-B.A./B.S. in Biology, Biochemistry, Immunology or related discipline with at least 10 years relevant experience or M.S. in a related filed with at least 6 years of experience.
-Demonstrated experience with molecular biology techniques (DNA/RNA/RT-PCR/ transfections), culture of cell lines and primary cells, flow cytometry, ELISAs, Westerns, functional assays (chemotaxis, calcium mobilization, etc).
-Demonstrated experience in the design, development and implementation of molecular assays.
-Ability to independently design and troubleshoot experiments, perform literature searches, work with automation equipment when necessary.
-Excellent oral/written communication skills and comfort in participating in a fast-paced team environment.

Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers.  As part of that commitment, Boehringer Ingelheim conducts pre-employment background investigations and drug screenings.  Boehringer Ingelheim is an equal opportunity employer. M/F/D/V

How to apply:  Please copy and paste the following link into your browser address bar:
http://appclix.postmasterlx.com/track.html?pid=ff80808127972f420127db1c82474564&source=aai

And search for job #RD00710.

Posted: April 16, 2010

  
 
 
The Benaroya Research Institute at Virginia Mason (BRI) is a center of scientific excellence in research and therapy of autoimmune diseases, such as diabetes, multiple sclerosis and arthritis, and promotes clinical and interdisciplinary research, particularly in cancer, neuroscience, and heart disease. BRI is a non-profit organization celebrating its 54th year as Washington State’s oldest medical research institute with over 200 employees and a $28 million budget for 2010. BRI offers a competitive salary and excellent benefits.

Position #: 10-21
Position: Staff Scientist
Department: Buckner Lab
Status: Full time (one to two year appointment)
Responsibilities and Qualifications: The Staff Scientist will be responsible for designing and performing experiments which will include the use of human T cells, siRNA knockdown and assessment of T cell function.

This position requires a Ph.D. or M.D. with relevant postdoctoral training in immunology or molecular biology. Skills required include utilization of tissue culture and molecular biology experience.

For application instructions please visit http://www.benaroyaresearch.org/employment and quote reference number 10-21 in your cover letter.
EEO – M/F

Posted: April 12, 2010

  
 
 

Senior Research Assistant/Associate
Brown University - www.brown.edu

POSITION SUMMARY: The grade 10/11 Senior Research Assistant/Associate applies extensive scientific and management methodologies specific to the laboratory with scientific vigor, advancing research efforts and minimizing research development risks with regard to quality, timelines, and funding.

The person in this position will design experiments in collaboration with the principal investigator, deviating from protocol when necessary, as well as design and carry out particular experiments completely independently. The individual should have extensive expertise in immunology and genetics. Individual must be willing to work with mice and order laboratory supplies, as well as help oversee a demanding laboratory with many members. The person may be asked to act as a liaison between the laboratory and other departments. Because of the nature of the project, expertise in cytokines in the context of immune responses to viral infections. (GRADE LEVEL WILL BE DETERMINED BY CANDIDATES' EDUCATION AND EXPERIENCE)  

QUALIFICATIONS: Bachelor of Science degree in related field (grade 11 - Masters) or equivalent combination of education/experience; Considerable laboratory experience (grade 10 - 5-7 years, grade 11 - 7-10 years), highly skilled in all techniques used in the lab, including flow cytometry, tissue culture, dissection, immunofluorescent microscopy, and western blotting; Demonstrated ability to design and analyze experimental protocols; data analysis skills; Excellent writing skills; experience writing grant proposals and contributing to scientific publications; Laboratory management experience including supervision and training; Ability to communicate professionally, effectively and confidently at all levels of the lab, and the extended organization.  

Apply online:  http://careers.brown.edu to Job No. M02292.

 

Brown University is an E-Verify Employer. Brown University is an Equal Opportunity/Affirmative Action Employer.

 

Denise Capoverde

Department Manager

Molecular Microbiology and Immunology

Division of Biology & Medicine

Brown University

Box G-B5

Providence, RI  02912

(401)863-9585

denise@brown.edu

Posted: April 8, 2010

  
 
 

Scientist – Biology
Johnson & Johnson Pharmaceutical Research & Development, LLC, La Jolla, CA

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine. 

The Immunology department is engaged in identifying, evaluating, and validating potential drug targets, with the goal of discovering new therapeutics in the areas of autoimmune and respiratory diseases. We are currently seeking a Ph.D. level scientist that will focus on cellular immunology.

The successful candidate will join the Translational Immunology group within the Immunology team. The key responsibilities will be evaluating the immunological impact of different potential drug targets during target exploration and validation, as well as enabling the immunology components of translational packages for drug candidates. The individual would work as part of a team to support and participate in the progression of drugs into pre-clinical and clinical development

In addition, they will be will be responsible for designing and performing experiments to evaluate drug targets under disease-relevant conditions, in distinct subsets of T and B cells, and innate immune cells, in order to extend our understanding beyond that in the current literature. Translational work will include evaluation of targets and drug candidates in tissues and blood cells from patients with autoimmune and respiratory diseases. 

A Ph.D. level scientist with immunology training and a focus on cellular immunology is required.  The candidate should be proficient in mouse and/or human immunological assays (flow cytometry including intracellular cytokine staining, T and B cell proliferation and cytotoxicity assays, Th1/Th2/Th17 T cell differentiation and activation cultures and cytokine response assays, mouse in vivo immune response models).  The individual should be a bench scientist with ability to train and supervise junior staff in cellular immunology techniques to address core immunology questions in the team.

As a valued team member, you’ll receive a competitive salary and great benefits including medical/dental, a 401(k), a pension plan and a comprehensive wellness program. If interested, please apply directly on-line at our web site www.jnj.com/careers noting Req. Code 7384100303. The Johnson & Johnson Family of Companies has a strong commitment to diversity and welcomes applications for all individuals.  EOE M/F/D/V

Application Time Table:  6 months

Posted: April 1, 2010

  
 
 
Scientist II/III, Immunology
FivePrime Therapeutics

Five Prime Therapeutics, Inc. is a clinical stage drug discovery and development company, focusing on novel therapeutic proteins, discovered through use of its world-class discovery platform. We are building a strong pipeline that currently includes products in development for cancer, metabolic disease, and immunological diseases. At FivePrime, we are committed to developing innovative therapeutics, cutting-edge technologies, and pursuing the highest quality science – a commitment that is reflected in our employees. Discover more about FivePrime at www.fiveprime.com.

The Position: We are currently seeking a highly motivated and innovative scientist to join our Immunology group.  The individual will be an important thought leader within the company by providing leadership in our expanding research programs.  Utilizing Five Prime’s unique discovery system, the scientist will direct a project aimed at identifying therapeutics for autoimmune diseases.  The candidate will also participate in the design and implementation of in vitro cell based assays, as well as studies aimed at validating and determining mechanism of action of therapeutic candidates.

Requirements

Education and Experience: Applicants must have a Ph.D. in immunology or related field with at least 4-8 years of experience, including post-doctoral experience.  The ideal candidate will be an outstanding scientist with experience in multiple models of autoimmunity and an understanding of human immunological mechanisms and pathways.  Industry experience in biopharmaceutical drug discovery is highly desirable.

Skills:
·   Expertise in immunology and autoimmunity is preferred.  Experience with in vivo models of autoimmunity and/or inflammation is preferred. 
·   Expertise in developing cell-based assays using a variety of cell types and a variety of assay readouts is a plus. 
·   Expertise in flow cytometry is highly preferred.  Experience utilizing a BD LSRII is a plus.
·   The ability to work as part of a cross-functional team and outstanding communication and presentation skills are required.
·   He/she will enjoy working as a member of a fast-paced multidisciplinary team in an entrepreneurial environment.

All applicants should apply via online application system: https://home.eease.com/recruit/?id=492381.

Posted: March 26, 2010

  
 
 
Research Scientist, Stanford University Histocompatibility, Immunogenetics, and Disease Profiling Laboratory, Department of Pathology, Stanford University

Position Description: The Histocompatibility, Immunogenetics, and Disease Profiling laboratory at Stanford University is seeking a Life Science Research Associate as a co-investigator to carry out translational research focused on the mechanism of intravenous immunoglobulin (IVIG) in the regulation of antibody production. The person in this position will take a leadership role in the planning and execution of the ongoing research program, while developing increasing independence.

You will provide leadership and technical expertise to investigate the mechanism of action of intravenous immunoglobulin in transplant patients. You will plan, execute, and interpret experiments designed to answer basic research questions; and propose next steps. You will become expert in background scientific literature on this and related subjects; present data to a mixed laboratory audience and to scientific meetings; and prepare results for publication in scientific journals. This position is intended for a scientist who can work with considerable autonomy and who will develop increasing levels of independence in pursuing research goals.

An understanding of the mechanism of action of IVIG may lead to more effective use of the therapy and to the development of alternative methods with even greater effectiveness. This project will involve many aspects of immune regulation and molecular immunology, including regulation of antibody production, antigen specificities in IVIG that are responsible for the activity, biochemical characterization of the active portion of IVIG, and so on. We are an active, modern clinical lab, and this research is expected to have a direct clinical impact.

This position offers an outstanding opportunity to participate in an ongoing successful program with the intention of establishing independent projects as they develop.

Position Requirements:  Ph.D. or M.D. degree in immunology or related field with minimum of 5 years laboratory experience. Methods development experience is preferred; some familiarity with the HLA system is desirable. Strong expertise in immunology and molecular biology, including several of these techniques: cell culture, protein purification, antibody manipulations (purification, fragmentation, conjugation, etc.), affinity chromatography, ELISA, Western blotting, flow cytometry, Luminex, Elispot, and basic molecular biology techniques. Experience with preparation of basic-science manuscripts for publication and making scientific presentations. Preference will be given to candidates with knowledge of and understanding of the HLA system, experience with grant proposal writing, and some demonstrated ability to manage and organize research lab activities. Candidate must be a self-starter and a good team player with strong communication and interpersonal skills, and is expected to be meticulous, highly organized, and capable of independent thinking.

Applications may be submitted before May 15, 2010.

Contact: Christine Martens, Ph.D., 3373 Hillview Avenue, Palo Alto, CA 94304, USA, 650-725-3974, cmartens@stanford.edu.

Posted: March 26, 2010

  
 
 
Scientific Program Manager: Immunity & Inflammation

We are seeking a Scientific Program Manager with a strong scientific background to help drive the success and growth of The Biomarkers Consortium, a public-private partnership managed by the Foundation for the National Institutes of Health (FNIH) on behalf of the National Institutes of Health (NIH), the Food and Drug Administration (FDA), the biopharmaceutical industry, and a broad range of academic and non-profit partners. 

The Immunity & Inflammation Scientific Program Manager will report directly to the Consortium Director and work with the members of the Consortium’s Immunity & Inflammation Steering Committee to identify, evaluate, gain approval for, and implement significant, large-scale projects designed to advance the state-of-the-art in developing biomarkers in such areas as osteoarthritis, COPD, and rheumatoid arthritis.  This is a non-research, program management position that requires outstanding interpersonal skills, and knowledge of medical research and its application to clinical practice. The ideal candidate also:

  • is goal-oriented, flexible, collegial, and interested in implementing public-private research partnerships;
  • possesses a PhD in a relevant scientific field or master’s degree with significant relevant experience;
  • is familiar with the field of immunity and inflammation;
  • has a minimum of 4 years of experience managing complex, technically-oriented projects;
  • has managed or has a working knowledge of translational medicine or development of therapeutics, including scientific data management, intellectual property, and publication issues; and
  • has experience in working with scientific researchers from diverse sectors (government, academia, and/or private industry).

Candidates must be detail-oriented, succinct in presentation, energetic, professional, proactive and have the ability to network with colleagues across the country.

The Scientific Program Manager provides expert advice and guidance on the operational aspects of The Biomarkers Consortium Immunity & Inflammation Steering Committee activities and is a key interface to other Consortium committees, including the Executive Committee and Project Teams formed under the Immunity & Inflammation Steering Committee. This is a high visibility position that will involve working with senior research leaders from private industry, government, academia, and non-profit and public advocacy groups.

Benefits: Fully paid medical and life insurance, 11 paid holidays, fully paid short-term and long-term disability insurance, and a generous 403(b) retirement plan. Salary is competitive and commensurate with experience.

The FNIH is an equal opportunity employer and does not condone or tolerate discrimination based on race, color, religion, sex, national origin, age, physical or mental disability, or sexual orientation.  

The Foundation employs only United States citizens and those non-U.S. citizens authorized to work in the United States in compliance with the Immigration Reform and Control Act of 1986.

How to Apply: Email your cover letter, resume, three references and your salary requirements to Subject: Program Manager, Immunity & Inflammation at resumes@fnih.org.

Posted: March 24, 2010

  
 
 

The Tolerance Assay and Data Analysis Group (TADA) of the Immune Tolerance Network (ITN) has an open position for a flow cytometry research analyst/scientist at their Bethesda, MD office. The ITN is a National Institutes of Health-funded research network created to facilitate the advancement of immune tolerance-inducing initiatives in human clinical practice. With over $30 million dollars in funding per year, the ITN is responsible for the selection, design and key aspects of the implementation of mechanistic, laboratory-based studies and clinical trials examining many of the most advanced experimental drugs and biologics in development today. 

The ITN has approximately 80 full-time members divided into the functional areas needed to design and carry out integrated mechanistic and clinical trials in several distinct disease areas including multiple auto immune diseases such as type I diabetes, lupus, psoriasis, rheumatoid arthritis, and including the induction of tolerance to transplants. The ITN currently has 30+ clinical trials in progress, many of which measure the dynamics of complex lymphocyte subpopulations using multi-parameter flow analysis.  

Requirements:  

The successful candidate will perform complex flow cytometry data analyses and must have extensive practical knowledge of flow cytometry including analysis of FCS files using multiple software applications. These include, but are not limited to FlowJo, CXP, ModFit , WinList and FCS Express. The candidate will manage schedules and timelines of sample analysis, generate and maintain standard operating procedures (SOPs) and oversee core laboratories' performance by means of quality assurance. The incumbent will be responsible for generating and implementing a quality assurance plan for flow cytometry assays performed in the core laboratories to ensure that all assays are reproducible and high quality.  The successful applicant will also be responsible for archiving and managing scientific data, meeting minutes and generating quality control reports.  

M.S. in Biotechnology or a related field and a minimum of three years of relevant experience, or B.S with five years experience is required. A strong background in immunology is preferred. The candidate must express strong interests in innovative research tools for new approaches for high throughput flow data analysis and visualization that can be implemented in flow cytometric data analysis as well as for quality assurance processes. These might include: 

*        Batch processing of a large amount of flow cytometry data
*        Data quality assessments
*        Identification of artifacts in sample preparation/handling & recommendation(s) for correction
*        Software tools for defining cell populations and automated gating
*        High throughput data visualization 

Other required skills include strong written and verbal communication, interpersonal and negotiation skills, and strong computer skills. 

To apply for this position please send CV and names of three references to Dr. Liu at zliu@immunetolerance.org.

Posted: March 15, 2010

  
 
 
 

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Updated: 09/02/2010