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Special Symposia and Lectures

President's Program and AAI Lifetime Achievement Award

AAI PRESIDENT’S ADDRESS AND PRESENTATION OF AAI LIFETIME ACHIEVEMENT AWARD

Supported through an unrestricted educational grant from Amgen Inc.

Saturday, April 17, 2004, 5:00 PM

Presentation of the 2004 AAI Lifetime Achievement Award will be made prior to the President’s Address.

Award Presentation
Introduction: Laurie H. Glimcher, AAI President, Harvard Sch of Pub Health and Harvard Med Sch
Awardee: Richard W. Dutton, Trudeau Inst.

President’s Address
Introduction by William E. Paul, NIAID, NIH

All's Well that Ends Well: Cell Fate Decisions in Lymphocytes

Laurie H. Glimcher, AAI President, Harvard Sch Pub Health and Harvard Med Sch

PRESIDENT'S SYMPOSIUM

Tuesday, April 20, 2004, 2:30 PM

Transcription Factors that Direct Lineage Commitment in Lymphocytes

Supported through an unrestricted educational grant from Genentech, Inc.

Chair: Laurie H. Glimcher, AAI President, Harvard Sch of Pub Health and Harvard Med Sch

Speakers:

Gerald R. Crabtree, Stanford U Sch Med
The interfacing of signaling and chromatin in lymphocyte development

I-Cheng Ho, Brigham & Women’s Hosp
Role of GATA-3 in T cell development and function

Dan R. Littman, HHMI, NYU Skirball Inst
Role of Runx family members in T cell development and gene silencing

Kathryn Calame, Columbia Coll Physicians & Surgeons
Blimp-1 and the development of hematopoietic cells

Distinguished Lectures

Chair: Leslie J. Berg, AAI Program Chair, U Massachusetts Med Ctr

Sunday, April 18, 5:00 PM
Kim Bottomly, Yale U Sch Med

Differential Activation of Subsets of CD4 T Lymphocytes

Supported through an unrestricted educational grant from Bristol-Myers Squibb Company

Monday, April 19, 5:00 PM
Lewis L. Lanier, UCSF

NK Receptors in Immunity and Autoimmunity

Tuesday, April 20, 5:00 PM
Jonathan Sprent, The Scripps Res Inst

Stimulating CD8 T Cells

AAI Minority Affairs Committee Guest Lecture

Supported through a grant from the FASEB/MARC Program

Tuesday, April 20, 2004, 10:30-11:30 AM

Introduction: Gerald Sonnenfeld, AAI Minority Affairs Committee Chair, Morehouse Sch Med

Speaker:

• Randy R. Brutkiewicz, Indiana U Sch Med
  CD1d-mediated antigen presentation to NKT Cells

Special Symposia

Monday, April 19, 1:30 PM

The Third Law of Immunology - Innate Immunity Instructs Adaptive Immunity: NIAID Symposium in Memory of Charles A. Janeway, Jr.

Sponsored by the National Institute of Allergy and Infectious Diseases, NIH.

Chairs: William E. Paul, NIAID, NIH; Charles J. Hackett, NIAID, NIH

Speakers:

• Anthony S. Fauci, NIAID, NIH
  Indebtedness of the immunology community to Charlie Janeway

Perspectives on Charlie Janeway--the Person and the Scientist

• Hugh O. McDevitt, Stanford U Sch Med
  Personal perspective
• William E. Paul, NIAID, NIH
  Personal perspective
• Alexander Rudensky, U Washington Sch Med
  Personal perspective

Cutting Edge Developments in Innate Immunity

• Kathryn V. Anderson, Mem Sloan-Kettering Cancer Ctr
  Pattern recognition and host defense in Drosophila
• Alan B. Ezekowitz, Harvard Med Sch
  Pattern recognition molecules in innate immunity
• Ruslan Medzhitov, Yale U Sch Med
  Toll pathway of host defense
• Ralph M. Steinman, Rockefeller U
  Dendritic cells at the interface between innate and adaptive immunity
• Douglas T. Fearon, U Cambridge
  A T cell transcription factor involved in memory

Saturday, April 17, 2004, 2:30 PM

AAI-NIAID Symposium: Contemporary Topics in Immunology

Chairs: Alison Deckhut Augustine, NIAID, NIH; Leslie J. Berg, AAI Program Chair, U Mass Med Ctr

Speakers:

• Amy H. Andreotti, Iowa State U
  Structural insights into the function and regulation of immunological tyrosine kinases
• Ellis L. Reinherz, Harvard Med Sch
  Molecular immunology and biodefense: smallpox as an example
• Sherie L. Morrison, U California, LA
  Antibody mediated protection against Cryptococcus neoformans: The role of different human constant regions
• Mark Davis, Stanford U
  Integrating molecular and cellular events in T-cell recognition

Sunday, April 18, 2004, 10:15 AM -12:15 PM

Masters of Disaster: The IL12 Cytokine Family and Its Role in Health and Disease

Supported through an unrestricted educational grant from Centocor, Inc.

Chair: Christopher A. Hunter, Univ Pennsylvania Sch Veterinary Med
Co-Chair: M. Michele Hogan, AAI

Speakers:

• Christopher A. Hunter: Welcome and overview
• Christopher A. Hunter, Univ Pennsylvania
  IL12/27 JAK-STAT signalling; and role in parasitic infection
• Daniel J. Cua, DNAX
  The role of IL12 and IL23 in autoimmune disease
• Robert A Seder, NIAID, NIH
  The role of IL12 in controlling differentiation of Th1 effector/memory cells: implications for vaccine development
• Alain H. Rook, Univ Pennsylvania
  IL12 for cutaneous T-cell lymphoma:Therapeutic effects and modulation of host immunity

Sunday, April 18, 2004, 12:30 PM

AAI Committee on Public Affairs: International Scientific Collaboration in an Era of Heightened Security

Chair: Jeffrey A. Frelinger, AAI Committee on Public Affairs Chair, U North Carolina, Chapel Hill

Speaker: George H. Atkinson, Science and Technology Adviser to the Secretary of State, U.S. State Department

Hear special guest speaker George H. Atkinson, Science and Technology Adviser to U.S. Secretary of State Colin Powell, address the important issue of international scientific collaboration in this post-9/11 era. He will discuss the effect of our nation’s new policies on travel to and from scientific meetings in the United States and on the employment of foreign scientists, including the foreign post-doctoral fellows who are crucial to much of the important research conducted in many U.S. laboratories.

Monday, April 19, 2004, 10:15 AM

AAI Veterinary Immunology Committee Symposium:

Bioterrorism Threats to Animal Agriculture

Sponsored through an unrestricted educational grant from the American Association of Veterinary Immunologists.

Chair: Douglas F. Antczak, Cornell U Coll of Vet. Med.

Speakers:

• Alfonso Torres, Cornell Col Veterinary Med
  Bioterrorism threat to animal agriculture in the US
• Paul Kitching, Nat. Ctr Foreign Animal Disease, Winnepeg
  The foot and mouth disease outbreak in the UK and the use of slaughter and containment to stop the outbreak
• Julio Barozzi, Embassy of Uruguay
  Advantages and disadvantages and outcomes of vaccination programs for foot-and-mouth disease control in South America to contrast the slaughter policy in effect in the UK
• Ronald Crystal, Weill Medical College, Cornell Univ
  Using gene-based strategies to immunize against agents of bioterrorism

Monday, April 19, 3:00 - 4:30 p.m.

Will You Still Fund Me Tomorrow? The Deficit, Biodefense, and the NIH Roadmap

Featured speakers: Elias Zerhouni, Director, NIH, Allen Spiegel, Director, NIDDK, NIH

Join Elias Zerhouni, Director of the NIH, and Allen Spiegel, Director of the NIDDK, NIH, in a panel discussion addressing how a radically changing environment will impact NIH grantees in the coming years. Drs. Zerhouni and Spiegel will discuss the prospects for NIH funding in light of increasing federal budget deficits, the need for biodefense spending, and the NIH Roadmap. They will also address how the Roadmap initiatives will complement or compete with investigator-initiated research and how the various institutes and centers will implement and plan for future Roadmap projects.

Attendees will have ample time to direct questions to the NIH leadership.

AAI Clinical Immunology Committee Tutorial

Saturday, April 17, 2004, 12:30 PM

Medical School for PhDs: An Overview of Human Disease and the Role of the Immune Response

Chair: David Hafler, AAI Clinical Immunology Committee Chair, Harvard Med Sch

Speakers:

• David A. Hafler, Harvard Med Sch
  Overview of the pathobiology of autoimmune disease: Multiple Sclerosis (MS) as a model
• Leeann Jensen, NCI, NIH
  Cancer and immunotherapy: where are we?
• Olivia Martinez, Stanford Med Sch
  Lymphomas as a result of immunosuppression: the transplant model
• Megan Sykes, Massachusetts Gen Hosp, Harvard Med Sch
  Organ and cellular transplantation
• Terri Laufer, U Penn
  Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)
• Kevan Herold, Columbia Univ
  Overview of the pathobiology of Type 1 diabetes (IDDM)

Special Award Lectures

Sunday, April 18, 2004, 2:30 PM

AAI-BD Biosciences Investigator Award and Lecture

Supported through an unrestricted educational grant from BD Biosciences

Introduction and Award Presentation: Laurie H. Glimcher, AAI President and John "Kip" Miller, BD Biosciences

Awardee: David G. Schatz, HHMI, Yale Univ. Sch. Med
Assembling and diversifying antigen receptor genes

Sunday, April 18, 2004, 3:30 PM

AAI-Huang Foundation Meritorious Career Award and Lecture

Supported through an unrestricted educational grant from The Huang Foundation

Introduction and Award Presentation: Laurie H. Glimcher, AAI President and Ernest Chun-Ming Huang, President, The Huang Foundation

Awardee: Michel C. Nussenzweig, HHMI, Rockefeller Univ.
Tolerance and the antibody system

Receptions

Monday, April 19, 2004, 7:00 PM

AAI Reception

Sponsored by BD Biosciences

National Museum of Women in the Arts
(invitation required)

Tuesday, April 20, 2004, 7:00 PM

President's Reception

Sponsored by BD Biosciences
(invitation required)
Hyatt, Farragut Square/Lafayette Park

Tuesday, April 20, 2004, 9:00 AM

AAI Minority Affairs Committee Reception/Breakfast

Convention Center, Rm 205
(by invitation only)

Guest Speaker: Milton Hernandez, Director, Office of Special Populations and Research Training, NIAID, NIH
NIH Research and Training: Funding Opportunities for the Minority Scientist

Monday, April 19, 2004, 9:30 PM - 12:30 AM

Young Experimental Scientists
Y.E.S. Mixer

Hyatt, Constitution Rm B

Monday, April 19, 2004, 6:00 PM

Oklahoma Medical Research Fund "Post-Doctoral Fellows and Graduate Student" Reception

Hyatt, Latrobe Rm

Sunday, April 18, 2004, 8:00 AM

Major Symposium A

Autoimmunity: Where Tolerance Goes Awry

Supported through an unrestricted educational grant from the Juvenile Diabetes Research Foundation International

Chairs: Vijay K. Kuchroo, Harvard Med Sch; Christophe O. Benoist, Joslin Diabetes Ctr

Speakers:

• Vijay K. Kuchroo, Harvard Med Sch
  Functional characterization of an autoimmune disease-associated CTLA-4 splice variant in regulating T cell responses
• Christophe O. Benoist, Joslin Diabetes Ctr
  Self, tolerance, autoimmunity
• Betty Diamond, Albert Einstein Coll of Med
  Regulation of B cell repertoire and autoimmunity
• Alexander Tarakhovsky, Rockefeller U
  Signaling mechanisms of tolerance failure
• Richard A. Flavell, Yale U Sch Med
  Regulation of the immune and autoimmune response
• Ann Marshak-Rothstein, Boston U Sch Med
  Complex activation of autoreactive B cells

Sunday, April 18, 2004, 8:00 AM

Major Symposium B

The Immunobiology of Th2 Responses, Allergy and Asthma

Chairs: Dale T. Umetsu, Stanford U Med Ctr; Jack A. Elias, Yale U Med Sch

Speakers:

• Dale T. Umetsu, Stanford U Med Ctr
  TIM-1, HAV and the hygiene theory of atopy: TIM-1 regulates the development of Th2 responses
• Jack A. Elias, Yale U Med Sch
  Chitinases in asthma pathogenesis
• Anjana Rao, Harvard Med Sch
  Transcriptional regulation of Th2 cytokine genes
• Ruslan Medzhitov, Yale U Sch Med
  Innate control of adaptive immunity
• Yong-Jun Liu, U Texas MD Anderson Cancer Ctr
  TSLP, dendritic cells and allergy
• Thomas J. Braciale, U Virginia Health Sci Ctr
  CD4 + and CD8 + T-cell interactions in virus infection and the control of Th2 responses

Monday, April 19, 2004, 8:00 AM,

Major Symposium C

Immune System Organogenesis

Chairs: Cynthia J. Guidos, Hosp. Sick Children Research Inst., Ellen Richie, U Texas MD Anderson Science Park

Speakers:

• Gary A. Koretzky, U Pennsylvania Sch. Med.
  SLP-76 is critical for blood vessel and lymphatic specification
• Nancy R. Manley, U Georgia, Athens
  Regulation of thymus organogenesis and thymic epithelial differentiation
• Howard T. Petrie, U Miami Med. Sch.
  Signals regulating lymphopoietic differentiation in the post-natal thymus
• Reina E. Mebius, Vrije Universiteit Med. Ctr, The Netherlands
  Cellular interactions in lymph node organogenesis
• Troy D. Randall, Trudeau Institute
  The development and function of lymphoid organs in the respiratory tract
• Nancy H. Ruddle, Yale U Sch. Med.
  Lymphoid organogenesis and neo-organogenesis: cytokines, chemokines and HEV

Monday, April 19, 2004, 8:00 AM

Major Symposium D

Immunotherapy 2004: Cancer to Autoimmunity

Chairs: Andrew C. Chan, Genentech, Inc., James P. Allison, HHMI, U California, Berkeley

Speakers:

• Andrew C. Chan, Genentech, Inc.
  B cells in disease and health - from bedside to bench
• James P. Allison, HHMI, U California, Berkeley
  Manipulation of T cell costimulation in tumor immunotherapy
• Mark X. Sliwkowski, Genentech, Inc.
  Targeting ligand-activated HER2/ErbB2 in solid tumors
• Jeffrey V. Ravetch, Rockefeller U
  Antibody effector pathways
• Gary A. Peltz, Roche Bioscience
  From genetics to therapeutics

Tuesday, April 20, 2004, 8:00 AM

Major Symposium E

The CATERPILLER/NOD/NALP Family of Proteins

Chairs: Jenny P.-Y. Ting, U North Carolina, Gabriel Nunez, U Michigan Cancer Ctr.

Speakers:

• Jenny P.-Y. Ting, U North Carolina
  CATERPILLER proteins in adaptive and innate immunity
• Gabriel Nunez, U Michigan
  NODs: role in innate immunity and disease
• Jeremy M. Boss, Emory U,
  Regulation of MHC class II genes
• Jurg Tschopp, U Lausanne, Switzerland
  The inflammasome: a molecular platform for the activation of pro-inflammatory caspases
• Daniel L. Kastner, NIAMS, NIH
  Fevers, genes, and history: natural selection and the systemic autoinflammatory diseases

Tuesday, April 20, 2004, 8:00 AM

Major Symposium F

Regulatory T Cells

Chairs: Alexander Y. Rudensky, HHMI, U Washington Sch. Med., Harvey Cantor, Dana Farber Cancer Inst./Harvard Med Sch.

Speakers:

• Shimon Sakaguchi, Kyoto U, Japan
  Naturally arising CD4+ regulatory T cells in immunologic tolerance
• Ethan M. Shevach, NIAID, NIH
  Activation and deactivation of regulatory T cell function
• Harald von Boehmer, Dana Farber Cancer Inst.
  Dynamics of regulatory T cells: switching them on and off in vivo
• Harvey Cantor, Dana Farber Cancer Inst.
  Regulatory and effector sublineages within CD4 and CD8 T cell subsets
• Alexander Y. Rudensky, HHMI, U Washington Sch. Med.
  The making of a CD25-positive regulatory CD4 T cell
• Anne O’Garra, Natl Inst Med Res, UK
  Development and function of IL-10-producing regulatory T cells: relationship with other regulators

Wednesday, April 21, 2004, 8:00 AM

Major Symposium G

Intracellular Infections: The Enemy Within

Chairs: JoAnne L. Flynn, U Pittsburgh Sch. Med., Michael N. Starnbach, Harvard Med. Sch.

Speakers:

• JoAnne L. Flynn, U Pittsburgh Sch. Med.
  T cells and TB: a race for the lungs
• Michael N. Starnbach, Harvard Med. Sch.
  Control of chlamydia infection requires the IFN-γ inducible lysosomal thioreductase (GILT)
• William F. Dietrich, Harvard Med. Sch.
  Genetics of host susceptibility to intracellular pathogens
• Karen L. Elkins, FDA/CBER
  Fighting the good fight against intracellular Francisella infection
• David L. Sacks, NIAID, NIH
  Role of CD4+CD25+ T cells in regulating innate and adaptive immune responses to Leishmania major
• Hao Shen, U Pennsylvania Sch. Med.
  Good and bad memories from an intracellular infection

Wednesday, April 21, 2004, 8:00 AM

Major Symposium H

Co-stimulatory Receptors and Ligands

Chairs: Arlene H. Sharpe, Brigham and Women’s Hosp., Michael Croft, La Jolla Inst. Allergy and Immunol

Speakers:

• Michael Croft, La Jolla Inst. Allergy and Immunol
  Control of T cell memory by OX40 and 4-1BB
• Arlene H. Sharpe, Brigham and Women’s Hosp.
  Role of new pathways in the B7:CD28 superfamily in regulating T cell activation and tolerance
• Kenneth M. Murphy, HHMI, Washington U Sch. Med.
  An update on the role of BTLA in lymphocyte regulation
• Randy J. Noelle, Dartmouth Med. Sch.
  Inducing transplantation tolerance: CD154 blockade and the function of regulatory T cells
• Linda S. Wicker, U Cambridge, England
  Natural genetic variation of the CTLA-4 molecule influences autoimmune disease
• Rene A. W. Van Lier, Academic Med. Ctr., The Netherlands
  Balancing effector T cell formation via CD27/CD70 interactions

NIAID Workshop

Saturday, April 17, 2004, 12:30 PM - 2:30 PM

Working with Dangerous Bugs: NIAID Resources for Biodefense Research

Chairs: Helen Quill, NIH/NIAI; Alison Deckhut, NIH/NIAID

Discussion of available and planned NIAID resources for investigators to facilitate immunological research in biodefense; biocontainment laboratories; reagents/tissue repositories; animal models; and a discussion of upcoming biodefense funding programs.

Saturday, April 17, 2004, 2:00 PM

John H. Wallace High School Teachers Workshop

Lessons in Immunology

Supported by NIH Grant R25AI 43872

Chair: John R. Schreiber, AAI Education Committee Chair, Case Western Reserve U

Speakers:

Kara Jon Christesen, Salem High Sch, Salem, NH; Aurora Merry, Salem High Sch, Salem, NH; Mentors: Andrew B. Onderdonk, Harvard U; Arthur O. Tzianabos, Harvard Med Sch
Using a modified elisa assay to show the transmission of a simulated disease and the subsequent identification of the bacterial agent

Gloria J. Gilliam, North High Sch, Omaha, NE; Mentor: Devendra K. Agrawal, Creighton U
Asthma and the immune system

Tammy Morgan, Lake Placid High Sch, Lake Placid, NY; Mentor: Peter C. Sayles, Trudeau Inst
Scientific methods now and then: a historical perspective

Amy J. Parent, Tupper Lake High Sch, Tupper Lake, NY; Mentor: Richard W. Dutton, Trudeau Inst
An online laboratory experience in the technique of RNA isolation, cDNA preparation, RT-PCR

Thomas E. Schmit, Hamilton High Sch, Hamilton, MT; Mentor: Frank R. DeLeo, NIAID, NIH, Hamilton, MT
Modulation of surface protein expression during phagocytosis induced apoptosis in human neutrophils

James F. Striebel, Corvallis High Sch, Corvallis, MT; Mentor: Kim J. Hasenkrug, NIAID, NIH, Hamilton, MT
Identification and analysis of Rfv3 genotype and determination of its mechanism of resistance to retrovirus induced disease

LeeAnn Vaughan, North High Sch, Omaha, NE; Mentor: Kristen M. Drescher, Creighton U
Genetic engineering: a journey into DNA science

Henry Kelly, President, Fed American Scientists; Kendra Bodnar, Fed American Scientists
Immune attack, an instructional tool to teach biology

Sunday, April 18, 2004, 12:45 PM

AAI Committee on the Status of Women Careers Program

Chair: Ellen Richie, AAI Committee on the Status of Women Chair, U Texas MD Anderson Cancer Ctr

Experienced scientists will serve as discussion leaders at roundtables. During the program they will lead informal discussions on a specific career issue/option. Men are encouraged to participate. See Committee on the Status of Women report on the May 2003 Program for more information.

Sampling of topics:

GENERAL: topics related to the environment you work in or want to work in

1. Academic research: general
2. Biotech and Industry: general
3. Governmental agencies: CDC/FDA/NIH
4. Clinic: Clinical and diagnostic immunology
5. Undergraduate Institutions: teaching, doing research part-time

TRANSITIONS: topics focused on a specific career stage

6. Graduate student to Post-doc: finding a post doc, interviewing
7. Post-doc to PI: finding a position, interviewing, negotiating, lab start-up
8. New PI: attracting students and post-docs, preparing for tenure
9. Mid-career: developing administrative and management skills/sabbaticals
10. Changing careers: moving from academia to industry, or vice versa

SPECIAL: topics for unique situations:

11. Career and Family: time management/family leave/professional couples
12. Integrity and Ethics: dealing with controversy, discrimination in the workplace
13. Technology Transfer: patent law, intellectual property, university industry collaborations
14. Politics of Science
15. Science Journalism

Special Session

Tuesday, April 20, 2004, 12:30 PM - 2:30 PM

How to Succeed in Science

Chair and Presenter: Jonathan W. Yewdell, NIAID, NIH

A senior AAI researcher will address the creative process in carrying out research and thinking about scientific questions. Dr. Yewdell will impart practical advice on daily lab life and on maximizing post-graduate opportunities. While intended for students, all meeting participants are welcome to join in the discussion.

Tuesday, April 20, 2004, 12:45 PM

AAI Business Meeting and Awards Presentation

Chair: Michele Hogan, AAI Executive Director
Annual report to AAI members on the state of the AAI and The Journal of Immunology, business affairs, and presentation of AAI Awards.

Awards to be Presented:

AAI Distinguished Service Award

• John R. Schreiber, Rainbow Babies Children’s Hosp., Case Western Reserve Univ.
• David. W. Scott, American Red Cross

AAI Excellence in Mentoring Award

• Frank W. Fitch, Univ. Chicago

Pfizer-Showell Travel Award

AAI-Huang Foundation Trainee Achievement Awards

AAI Junior Faculty Travel Awards

AAI Minority Scientist Travel Awards

AAI Awards Program Information

Other Awards being presented during EB2004:

• AAI Lifetime Achievement Award
• AAI-BD Biosciences Investigator Award and Lecture
• AAI-Huang Meritorious Career Award Lecture

Committee and Other Meetings

• AAI Council Meeting (Day 1) (by invitation), 12:00 PM, Friday, April 16, Hyatt, Roosevelt Rm
• AAI Council Dinner (by invitation), 7:00 pm, Friday, April 16, TBA
• AAI Council Meeting (Day 2) (by invitation), 8:00 AM, Saturday, April 17, Hyatt, Roosevelt Rm
• AAI Committee on Public Affairs Meeting (by invitation), 11:00 AM, Saturday, April 17, Hyatt, Latrobe Rm
• AAI Clinical Immunology Committee Meeting (by invitation), 4:00 PM, Saturday, April 17, Convention Center, Rm203B
• The Journal of Immunology Editorial Board Meeting and Dinner (by invitation),
  Sponsored by Cadmus Communications Corporation
  6:30 PM, Saturday, April 17, Hyatt, Latrobe Rm
• AAI Committee on the Status of Women Meeting, 7:00 AM, Sunday, April 18, Hyatt, Wilson Rm
• NIAID Focus Group Meeting, (by invitation), 7:00 AM, Sunday, April 18, Hyatt, Latrobe Rm
• AAI Finance Committee Meeting (by invitation), 7:30 AM, Sunday, April 18, Hyatt, Renwick Rm
• AAI Minority Affairs Committee Meeting (by invitation), 11:00 AM, Sunday, April 18, Hyatt, Wilson Rm
• AAI Program Committee Meeting and Dinner (by invitation), 6:30 PM, Sunday, April 18, Hyatt, Latrobe Rm
• AAI Education Committee Meeting (by invitation), 10:00 AM, Monday, April 19, Hyatt, Wilson Rm
• Assn. of African Biomedical Scientists Business Meeting, 3:00 PM, Monday, April 19, Hyatt, Wilson Rm

Monday, April 19, 2004, 2:45 PM

Association of Medical Laboratory Immunologists (AMLI)

Model Systems that Drive Clinical Approaches to Autoimmune and Inflammatory Diseases

Chairs: C. Lynne Burek, Johns Hopkins U Sch Med; Barbara Detrick, Johns Hopkins U Sch Med

Speakers:

• Noel R. Rose, Johns Hopkins U
  Inflammatory heart disease: mechanisms and mediators
• John Hooks, NEI, NIH
  Experimental coronavirus retinopathy: genetic and autoimmune factors
• C. Lynne Burek, Johns Hopkins U Sch Med
  Iodine: an environmental trigger of thyroiditis
• Marsha Wills-Karp, Childrens Hospital Med Ctr, Cincinnati
  Asthma Pathogenesis: lessons from an animal model

Monday, April 19, 2004, 2:45 PM

American Society of Transplantation (AST)

Contributing Elements to Chronic Allograft Rejection

Chairs: D. Keith Bishop, U of Michigan Med Sch, Charles G. Orosz, Ohio State U

Speakers:

• D. Keith Bishop, U of Michigan
  Connective tissue growth factor and chronic allograft rejection
• Wayne W. Hancock, Children's Hospital of Philadelphia
  Chemokine receptors and chronic rejection
• Elaine F. Reed, U of Claifornia, Los Angeles
  The role of antibodies in chronic allograft rejection
• Ana J. Coito, The Dumont - UCLA Transplant Center
  The Fibronectin, extracellular matrix components and chronic allograft rejection
• Charles G. Orosz, Ohio State U
  TGF beta, thrombospondin and chronic allograft rejection

Sunday, April 18, 2004, 12:30 PM

American Society for Tropical Medicine & Hygiene (ASTMH)

T Cell Differentiation and Function in Parasitic Helminth Infection

Chairs: William C. Gause, USUHS, Miguel A. Stadecker, Tufts U Med. Sch.

Speakers:

• William C. Gause, USUHS
  Requirements for Ag-specific Th2 cell development and expansion in vivo
• Edward Pearce, U Pennsylvania
  Regulatory T cells allow Th2 response polarization during schistosomiasis
• Tom Wynn, NIAID, NIH
  Modulation of IL-13 effector function by IL-13Ra2
• Miguel A. Stadecker, Tufts U
  The immunobiology and genetics of Th1 polarization in high pathology schistosomiasis
• Richard Grencis, U of Manchester, UK
  Regulation, resistance, susceptibility and gut dwelling

Sunday, April 18, 2004, 2:45PM

Clinical Immunology Society (CIS)

Hereditary Periodic Fevers

Chair: Daniel L. Kastner, NIAMS, NIH

Speakers:

• Deborah L. Gumucio, U MI
  Familial Mediterranean fever (FMF)
• Mike McDermott, Royal London Sch Med
  TNFRSF1A-associated periodic syndrome (TRAPS)
• Raphaela Goldbach-Mansky, NIAMS, NIH
  Neonatal-onset multisystem inflammatory disease (NOMID)

Sunday, April 18, 2004, 2:45PM

Canadian Society for Immunology (CSI)

Signaling and Innate Immunity

Chairs: Paul Kubes, U Calgary

Speakers:

• Kamala Patel, U Calgary
  Endothelial mechanotransduction -- a role for leukocytes
• Myron Cybulsky, U Toronto
  Integrin activation during adhesion
• Wen-Chen Yeh, U Toronto
  Detection of bacterial products- signaling through IRAK4 and the TLRs
• Jean Marshall, Dalhousie U
  Mast cell responses to pathogens
• Sergio Grinstein, U Toronto
  Signaling and the phagolysosome

Monday, April 19, 2004, 2:45 PM

International Society for Developmental and Comparative Immunology (ISDCI)

Remarkable Complexity of Immune Recognition in the Invertebrates

Chair: Martin Flajnik, U Maryland Sch Med

Speakers:

• Paul Gross, Medical U South Carolina
  Variability in anti-microbial peptides: sources, specificity, significance, scampi
• Anthony De Tomaso, Stanford U
  Multiple processes diversify a putative allorecognition receptor in a protochordate
• L. Courtney Smith, George Washington U
  Unexpected diversity in a putative anti-microbial protein from a sea urchin
• Eric Loker, U New Mexico
  Diversity of IgSF genes in an invertebrate (snail)

Tuesday, April 20, 2004, 10:15 AM

International Society for Interferon and Cytokine Research (ISICR)

Frontier of Interferon (IFN) and Cytokine Research

Chair: Keiko Ozato, NICHHD, NIH

Speakers:

• Marc Ghany, NIDDK, NIH
  IFN therapy for HCV patients
• Tomohiko Tamura, NICHD, NIH
  IRFs and IFN/cytokine production in dendritic cells
• John Hiscott, McGill U
  IRF3 activation and IKK
• Keji Zhao NHLBI, NIH
  The role of the chromatin remodeling complex BAF in IFN/viral responses

Sunday, April 18, 2004, 10:15 AM

PsychoNeuroImmunology Research Society (PNIRS)

The Alteration of Health by the Hormonal Response to Stress

Chair: Bruce S. Rabin, U Pittsburgh

Speakers:

• William B Malarkey, Ohio State U
  Hormonal changes and resulting immune alterations that occur when the brain responds to stress by altering homeostasis
• Andrew H. Miller, Emory U Sch. Med.
  Role of stress-responsive neuroendocrine pathways in the development of cytokine-induced depression
• Willem J. Kop, USUHS
  Effects of stressor induced hormonal alteration on cardiovascular disease and immune function
• Bruce S. Rabin, U Pittsburgh
  Behaviors to buffer the effect of stress on immune function and health

Sunday, April 18, 2004, 12:30 PM

Society for Mucosal Immunology (SMI)

Function of Epithelia Cells in Mucosal Host Defense and Immune Regulation

Chair: Richard S. Blumberg, Harvard Med Sch

Speakers:

• Richard S. Blumberg, Harvard Med Sch
  FcRn mediated regulation of immune-complex transport to mucosal dendritic cells
• Martin Kagnoff, UCSD
  Microbial: Epithelial interactions in the regulation of chemokine expression by intestinal pathogens
• Lora Hooper, U Texas Southwestern
  Paneth cell regulation and innate microbial resistance by commensal lumenal bacteria
• Sean Colgan, Harvard Med Sch
  Leukocyte: epithelial interactions and their regulation in inflammation

Sunday, April 18, 2004, 2:45 PM

Society for Natural Immunity (SNI)

Innate Immunobiology and Host Defense

Chair: Yong-Jun Liu, MD Anderson Cancer Ctr; Wayne Yokoyama, HHMI, Washington U St. Louis

Speakers:

• Yong-Jun Liu, MD Anderson Cancer Center
  Cross-talk between epithelial cells and dendritic cells
• Virginia Pascual, Baylor Institute for Immunology Research
  Interferon-producing plasmacytoid pre-dendritic cells link innate and adaptive immunity
• Wayne M. Yokoyama, HHMI and Washington U St. Louis
  Host natural killer cell and pathogen interactions during viral infection
• Veronika Groh, Fred Hutchinson Cancer Center
  Immunobiology of the human NKG2D receptor

If selected by the AAI Block Chairs, authors have the opportunity to present their abstracts in oral presentations during block symposia held throughout the meeting. Abstracts presented in block symposia are required to also be presented in poster sessions, giving scientists a chance to discuss data with authors first-hand.

List of Block Symposium for EB 2004

Saturday, April 17
12:30PM-2:30PM

• Regulation of Suppression and Tolerance Induction - E. Shevach; E. Field , Rm 202A
• Genetic Regulation of the Immune System: Molecular Aspects of Repertoire Formation, Recombination, Isotype Switching, Somatic Mutation - B. Blomberg; W. Dunnick, Rm 202B
• Genetic and Genomic Analysis of Autoimmunity - W. Wakeland; C. David, Rm 201

2:45PM-4:45PM

• Immune Regulation at Mucosal Sites - C. Whitacre; J. Braun, Rm 202A
• Tumor Associated Pathobiology and Immunosuppression - J. Finke; K. McDonagh, Rm 202B
• Adhesion Molecule Regulation of Leukocyte Migration and Function - K. Ley; S. Simon, Rm 201

Sunday, April 18
8:00AM-10:00AM

• Innate Immunity to Microbes - B. Pulendran; L. Brossay, Rm 202A
• Antigen Presenting Cells: Activation and Function - S. Kovats; J. Wilder, Rm 202B
• Leukocyte Trafficking in Inflammatory Disease - J. Mountz; D. Bullard, Rm 201
• Chemokine and Cytokine Signaling and Development - J. Farber; C. Putterman, Rm 206
• Adaptive Immune Response Regulation during Parasitic and Fungal Infections - M. McDowell; T. Wynn, Rm 207A

10:15AM-12:15PM

• The Downside of the Immune Response to Pathogens: Immunopathogenesis - J. Durbin; M. Monick, Rm 202B
• Induction of Immunity: APC and Pathogens - M. Starnbach; C. Harding, Rm 201
• Regulation of Signaling Pathways in Immune Cells - G. Bishop; P. Correll, Rm 206

12:30PM-2:30PM

• Antibodies B Cells and Complement in Autoimmunity - G. Tsokos; D. Scott, Rm 202A
• Tolerance and Regulation in Autoimmunity - H. Zaghouani; V.K. Kuchroo, Rm 207A

2:45PM-4:45PM

• Leukocyte Trafficking in Adaptive Immunity - U. von Andrian; N. Ruddle, Blrm C

Monday, April 19
8:00AM-10:00AM

• Antigen Processing and Presentation - J. Blum; P. Jensen, Rm 201
• Development of Innate Immunity - J. Platt; L. Jaso-Friedmann, Rm 202A
• Transplantation Immunology II - G. Brown; P. Felsburg, Rm 202B
• T Cell Homeostasis - P. Fink; M. Nagarkatti, Rm 206
• T Cells and Pathogens - J. Flynn; T. Braciale, Rm 207A

10:15AM-12:15PM

• Innate Immune System Activation in Parasitic and Fungal Infections - S. Luckhart; T. Nutman, Rm 201
• Cytokines, Immune Initiation and Cell Development - G. van Seventer; I. Williams, Rm 202B
• Mechanisms of Costimulation and Anergy Induction - P. Fink; A. Wells, Rm 206
• Effector and Memory Cell Generation and Activation - R. Siegel; D. Farber, Rm 207A

12:30PM-2:30PM

• Immunotherapy for Autoimmune Diseases - R. Caspi; M. von Herrath, Blrm A
• Vaccines and Adjuvants - J. Berzofsky; D. Pascual, Rm 202A

Tuesday, April 20
8:00AM-10:00AM

• Cytokine Regulation, Polymorphisms and Chromatin - K. Sullivan; G. Tsokos, Rm 201
• Microbial Activation of Host Defense Mechanisms - A. Sher; R. Ashman, Rm 202A
• Mast Cells/Basophils and the Regulation of Allergic Reactions - S. Galli; C. Macaubas, Rm 206
• B Cell Development/ Homeostasis - R. Gerstein; J. Telfer, Rm 207A

10:15AM-12:15PM

• Genetic Regulation of the Immune System: Transcriptional Regulation of the Immune System - B. Birshtein; E. Max, Rm 201
• Complement Fc Receptors and Acute Phase Proteins - V. Holers; T. Du Clos, Rm 206
• Mucosal Immune Responses to Enteric Infection - C. Nagler-Anderson; W. Gause, Rm 207A

12:30PM-2:30PM

• Regulation and Evasion of the Immune Response by Pathogens - Y. Hahn; P. Katsikis, Blrm A
• Immunopathogenetic Mechanisms of Autoimmunity - D. Harlan; Y. Chen, Rm 202B
• Asthma and IgE - N. Lukacs; R. DeKruyff, Rm 201
• Cancer Vaccines and Immunotherapies - S. Abrams; R. Wiltrout, Rm 206
• Transplantation Immunology I - H. Shirwan; E. Bloom, Rm 207A

Wednesday, April 21
8:00AM-10:00AM

• Autoimmunity in the Central Nervous System - S. Miller; P. Lehmann, Rm 202A
• Signaling in Innate Immunity - J. Ting; P. Correll, Rm 202B
• T Cell Development, Stem Cells, Cell Survival - J. Zuniga-Pflucker; R. Mittler, Rm 201
• Soluble Mediators of the Immune System - P. Kubes; A. Marshall, Rm 206

10:15AM-12:15PM

• Cytokines and Autoimmune Disease - A. Infante, Rm 202A
• Signal Pathways in Immune Cell Regulation and Activation - J. Zuniga-Pflucker; P. Schwartzberg, Rm 202B
• Anti-Tumor Effector Cells, Mechanisms of Tumor Rejection and Modulation of Tumor Immunity - E. Sotomayor; W. Chambers, Rm 201

Posters will be displayed Sunday through Wednesday in the Convention Center Exhibit Halls from 8 AM-5 PM, with authors present from 12:30PM - 1:30 PM.

TEACHING POSTER SESSIONS

Recognizing that techniques and issues related to teaching and the use of computers in research and teaching cross all biomedical disciplines, EB 2004 will combine education posters from all participating societies into three special poster sessions. Although posters will be on display during exhibit hours Sunday through Tuesday, authors are required to be present during a scheduled day and time for demonstration, which will be listed in the Program. Authors must prepare a standard-sized poster in addition to the demonstration.

Computers in Research and Teaching - Topic Category 8100-EB
Demonstrate collegial (not for sale) software for research and teaching purposes. A special area of the exhibit hall will have both IBM PC compatible and MacIntosh computers with Internet access. For more information, please contact Dr. Jerry Collins at the Department of Biomedical Engineering, Vanderbilt University, Nashville, TN. Telephone 615-322-3003, Email: jerry.collins@vanderbilt.edu

Teaching with Models and Simulations - Topic Category 8200-EB
This special poster session features the use of models,demonstrations and simulations to teach. Authors are encouraged to bring the actual materials that they use for teaching. Tables and electrical outlets will be available at each poster board.

Teaching, Learning and Testing in the Biological and Biomedical Sciences - Topic Category 8300-EB
This is for all other teaching/education related posters, regardless of discipline, that do not require a computer and do not involve a demonstration. In particular, posters on the use of technology in teaching, not involving demonstrations of a particular software, should be submitted to this category.

GENOMICS SYMPOSIUM AND POSTER SESSION:

Health Disparities in Diabetes: Genetic and Therapeutic Applications

Organized by FASEB MARC Program Advisory Board. Sponsored by FASEB Career Resources and MARC Program Office. Coordinators: Thomas D. Landefeld, Ph.D. (Associate Dean for Faculty Affairs and Scholarly Activities, California State University-Dominguez Hills, Carson, CA) and Sunny E. Ohia, Ph.D. (Dean, University of Houston, College of Pharmacy, Houston, TX). Moderator: Griffin P. Rodgers, M.D. (Deputy Director of NIDDK/NIH, Bethesda, MD).

KEYNOTE SPEAKERS: Griffin P. Rodgers, M.D. (Deputy Director of NIDDK/NIH, Bethesda, MD); James R. Gavin III, M.D., Ph.D. (President, Morehouse School of Medicine, Atlanta, GA); Charles N. Rotimi, Ph.D. (Associate Professor, Howard University, Washington, DC); Nedal H. Arar, Ph.D. (Assistant Professor, University of Texas Health Sciences Center, San Antonio, TX).

RELATED POSTER SESSION: At least 20 posters from students and postdoctoral fellows involved in research related to the genetic basis of diabetes and its treatment in diverse populations will be selected to be displayed during the symposium and reception/mixer. Travel awards (including meeting registration) for poster presenters included in this special session will be available through the FASEB MARC Program.

For further information, please contact Jacquelyn Roberts, Program Director, FASEB MARC Program, 9650 Rockville Pike, Bethesda, MD 20814-3998. Or visit the FASEB/MARC page.

EB  2004 PUBLIC AFFAIRS WORKSHOPS AND SYMPOSIA

SATURDAY, APRIL 17

HUMAN RESEARCH PROTECTIONS 1A: HOW TO NAVIGATE HUMAN SUBJECT PROTECTION REGULATIONS

9:00 AM – 11:00 AM, CONVENTION CENTER, ROOM 101

This workshop will provide an introduction to principles of bioethics and current U.S. federal regulations for protecting human subjects involved in research. The workshop will describe a comprehensive program of protections that an institution can provide to effectively protect human subjects and simultaneously conduct good scientific research. Emphasis will be on the roles of Institutional Review Boards (IRBs) and investigators in protecting research subjects and will include a comparison of the "Common Rule" with HIPAA concerning the use of human biological materials. Note: There is no charge for this session, but seating is limited so you must register to attend.

"IACUC 101" FOR SCIENTISTS

11:00 AM – 3:00 PM, CONVENTION CENTER, ROOM 146B

A half-day symposium on the workings of the Institutional Animal Care and Use Committee (IACUC) will be presented. This program, organized by the American Physiological Society Animal Care and Experimentation Committee, is a condensed version of the popular "IACUC 101" program. It is intended to help research scientists understand the roles and responsibilities of the IACUC and will give special attention to compliance issues most pertinent to academic institutions. This session will provide information useful to scientists who serve on IACUCs as well as those whose protocols require IACUC review. Along with the formal presentations, there will also be opportunities to raise questions with representatives of USDA, OLAW, and AAALAC. Note: There is no charge for this session, but seating is limited so you must register to attend. Visit http://www.the-aps.org/pa/IACUC/eb04.htm for program and registration information.

MAKING SCIENCE NEWS -- http://www.the-aps.org/press/conference/eb04/sciencenews.htm

2:00 PM – 5:00 PM, CONVENTION CENTER, ROOM 140A 

The goal of this symposium is to familiarize scientists with how the media works. The ever expanding interest in scientific news is an opportunity to assist in public understanding of and public support for biomedical research.  Helping scientists to take advantage of these opportunities is the aim of this symposium.  A panel of three journalists will offer their insight into what makes science news and the best practices for getting scientific research covered. Contact: Stacy Brooks at 301-634-7253 or sbrooks@the-aps.org.

SUNDAY, APRIL 18

INTERNATIONAL SCIENTIFIC COLLABORATION IN AN ERA OF HEIGHTENED SECURITY 

12:30 PM – 2:30 PM, CONVENTION CENTER, ROOM 201

Hear special guest speaker George H. Atkinson, Ph.D., Science and Technology Adviser to U.S. Secretary of State Colin Powell, address the important issue of international scientific collaboration in this post-9/11 era.  He will discuss the effect of our nation’s new policies on travel to and from scientific meetings in the United States and on the employment of foreign scientists, including the foreign post-doctoral fellows who are crucial to much of the important research conducted in many U.S. laboratories.  Contact: Lauren Gross at AAI at lgross@aai.faseb.org.

THE NEW CSR REVIEW PROCESS: AN NIH REVIEW

1:00 PM – 2:30 PM, CONVENTION CENTER, ROOM 147A

This session will present an overview of the changes to Initial Review Groups at NIH’s Center for Scientific Review that are being implemented as a result of the recommendations of the Panel on Scientific Boundaries of Review.

MONDAY, APRIL 19

SCIENTIFIC AND REGULATORY CHALLENGES INVOLVING DIETARY SUPPLEMENTS AND BOTANICAL PRODUCTS

12:30 PM – 2:00 PM, CONVENTION CENTER, ROOM 143/AB

Confirmed Speakers:

Mark McClellan, Commissioner, Food and Drug Administration

Paul Coates, Director, Office of Dietary Supplements, NIH

Stephen Straus, Director, National Center for Complementary & Alternative Medicine, NIH.

Topics to be addressed include: how to promote a stronger scientific foundation at the FDA and the need to promote better health through better research; how new collaborations with NIH will help to improve our understanding of the underlying mechanisms of action and help to improve safety and efficacy of these products; research opportunities for the extramural community; and regulatory perspectives on the Dietary Supplement Health & Education Act of 1994 (DSHEA). 

Contact: Jim Bernstein at 301.634-7062 or jbernstein@aspet.org

WILL YOU STILL FUND ME TOMORROW? THE DEFICIT, BIOTERROR, AND THE NIH ROADMAP 

3:00 PM – 4:30 PM, CONVENTION CENTER, ROOM 207B 

Join NIH Director Elias Zerhouni, M.D., and NIDDK Director Allen Spiegel in a panel discussion  addressing how a radically changing environment will impact NIH grantees in the coming years.  Drs. Zerhouni and Spiegel will discuss the prospects for NIH funding in light of increasing federal budget deficits, the need for biodefense spending, and the NIH Roadmap.  They will also address how the Roadmap initiatives will complement or compete with investigator-initiated research and how the various institutes and centers will implement and plan for future Roadmap projects.  Contact: Tracy Lawless @ tlawless@faseb.org.

TUESDAY, APRIL 20 

SUSTAINING INTEGRATIVE & ORGAN SYSTEMS SCIENCES: PROBLEMS, OPPORTUNITIES, SOLUTIONS 

12:30 PM – 2:00 PM, CONVENTION CENTER, ROOM 143C

Confirmed Speakers: 

Jerry Buccafusco, Medical College of Georgia

Gerald Schaefer, Wil Research Laboratories, Inc.

Steve Zeisel, University of North Carolina

Irv Zucker, University of Nebraska

Stanley J. Wiegand,Regeneron Pharmaceuticals, Inc.

Peter Preusch, National Institutes of Health

The advent of molecular biology has produced a vast wealth of information on human health and disease.  However, there has been a diminishment in the number and ability of trained investigators – and students pursuing training and research – in the integrative and organ systems sciences.   Science cannot effectively study disease or treatments for a disease simply by using isolated molecules, cells, or organs.  Speakers will give their perspectives on the challenges and opportunities for enhancing the integrative & organ systems sciences by addressing its impact on both academic and industrial concerns.  Contact:  Jim Bernstein at 301.634-7062 or jbernstein@aspet.org

Travel Awards for Mentors with Students and Poster/Oral Presenters (Students/Postdoctoral Fellows)

The FASEB MARC Program will be sponsoring EB2004 Travel Awards to help support the participation of faculty/mentors, postdoctoral fellows, and students from minority institutions (MIs) and historically black colleges and universities (HBCUs). The travel awards are funded up to $1,250 each for travel-related expenses. In addition, meeting registration (at the advance registration rate) will be provided to the award recipients. Travel awards are provided as reimbursements after the meeting. The travel awards are supported by a federal training grant from the NIGMS/NIH, therefore, only U.S. citizens and permanent residents of the U.S. are eligible for the travel awards. Underrepresented minority faculty, students, and postdoctoral fellows from majority institutions are also eligible to apply for the travel awards.

NIH Grant Seminar Workshops

The FASEB Career Resources and MARC Program Office in association with the National Institutes of Health (NIH) will offer a three-part grant seminar workshop in the Career Resources Center/Placement Service at the Experimental Biology 2004 Annual Meeting. Dr. Anthony M. Coelho, Jr., Review Policy Officer at NIH, will chair the workshops. EB 2004 registration is required to participate in the seminars. Advance seating reservations are required.

Peer Review of NIH Grants - Part I

This workshop is focused on providing information on how to understand the peer review process, which is essential to competing successfully for funding. The workshops also provide an overview of how scientific peer review is carried out at NIH.

Grant Writing for Success - Part II

This workshop provides an introduction to factors that contribute to applications that succeed in obtaining research funding. This presentation is focused on the fundamental principles of successful grant writing, the most common reasons that grant applications fail, how to make an application "reviewer friendly", how to meet the needs of the reviewers and the funding agency, how to avoid the need for resubmission and tips and strategies for resubmitting, including what should and what should not be done if resubmission becomes necessary.

NIH Mock Study Section - Part III

This workshop provides participants with an overview of the working dynamics of peer review at NIH. Participants will see the peer review process in action.

IMPORTANT: Handouts and resource materials for each seminar workshop will be provided for the participants who make advance seating reservations. The deadline date to make the advance reservations is Friday, April 9, 2004.

For further information on the MARC Travel Awards and NIH workshops, please contact Lisa Dennison or Jacquelyn Roberts at the FASEB Career Resources and MARC Program Office, 9650 Rockville Pike, Bethesda, MD 20814-3998; Telephone: 301-634-7930; Email: marc@faseb.org.