The Necessity of Death in Life
A Unit of Apoptosis

Developed by: Gina R. Martin
© American Association of Immunologists 1998

Special Note:
Before beginning this unit the teacher should review the equipment, supplies, and materials in Lesson Three of this unit. All of these items may be purchased from a science education supplier or borrowed from another school or institution (if they are willing to loan).

Lesson One: What is Apoptosis?

Objectives:

• The student will be able to identify the characteristics of an apoptotic cell.
• The student will be able to identify and describe the role of the cell membrane, nucleus, and mitochondria in apoptosis.
• The student will be able to compare the similarities and differences between healthy and apoptotic cells.

Lesson Two: What is the Role of Apoptosis in Diseases of the Human Body?

Objectives:

• The student will be able to describe the role of apoptosis in the healthy human body.
• The student will be able to describe the role of apoptosis in human disease.
• The student will be able to compare and contrast the roles of apoptosis in the healthy and diseased human body.
• The student will be able to compare and contrast the role of apoptosis among cancer, neurodegenerative disorders (Alzheimer's and Parkinson's), and AIDS.

Lesson Three: Inducing Apoptosis

Objectives:

• The student will be able to induce apoptosis in amphibian spleen cells.
• The student will be able to identify apoptotic cells.
• The student will complete a laboratory investigation using the scientific method.

Lesson Four: Apoptosis Assessment

Objectives:

• The student will demonstrate his or her knowledge of characteristics which identify apoptosis.
• The student will demonstrate his or her knowledge of apoptosis in the healthy human body.
• The student will demonstrate his or her knowledge of apoptosis in the diseased human body.
• The student will demonstrate his or her knowledge of the role of apoptosis in human disease and how this role affects the human body.

To receive a copy of this curriculum, please contact: The American Association of Immunologists, telephone: (301) 634-7178, fax: (301) 634-7887, email infoaai@aai.org.