Teaching Material Archive


Overview of the Immune System and Immunological Assays with Real World Connections
Cassandra Bonvissuto, Poland Seminary High School, Poland, OH
MentorProsper N. Boyaka, Ph.D., The Ohio State University, Columbus, OH

Applying Molecular Biology Techniques to Assess Bacterial Infection
Jason Econome
, Stuyvesant High School, New York City, NY
Mentor: Betty Diamond, M.D., The Feinstein Institute for Medical Research, Manhasset, NY

The Basics of Immunology: An Introductory Unit for High School Junior and Senior Students
Heather Potts, Wayne Valley High School, Wayne, NJ
MentorPatricia Fitzgerald-Bocarsly, Ph.D., Rutgers New Jersey Medical School, Newark, NJ

Immunodeficiencies: From Animal Models to the High School Classroom
Victoria Salo, Biddeford High School, Biddeford, ME
Mentor: Ling Cao, M.D., Ph.D., University of New England, Biddeford, ME

The Use of Transgenic Animals in the Study of Colitis: The Link between Molecular Biology and Immunology
Rebecca Thrash, Alabama School of Fine Arts, Birmingham, AL
MentorLaurie E. Harrington, Ph.D., University of Alabama, Birmingham, AL

Can We Save Them? Using ELISAs to Determine the IL-6 Levels in Septic Patients
Gina Castellanos Ellsworth, Haverhill High School, Haverhill, MA
Mentor: Daniel G. Remick, M.D., Boston University School of Medicine, Boston, MA

Using the Wax Moth Larvae as a Model to Study the Immune System
Antonio Gamboa, Garey High School, Pomona, CA
Mentor: Stephen A. O'Barr, Ph.D., Western University of Health Sciences, Pomona, CA

Investigating the Role of Different Food Sources on the Microbiome of
Drosophila melanogaster
Aaron Mathieu, Acton-Boxborough Regional High School, Acton, MA
MentorNeal Silverman, Ph.D., University of Massachusetts Medical School, Worcester, MA

Mind the Gap: Utilizing Borrelia burgdorferi, causative agent of Lyme Disease, as a model to study cells bridging innate and adaptive immunity
Sarah Peterson, Denver Public Schools, Denver, CO
MentorMark J. Soloski, Ph.D., Johns Hopkins University School of Medicine, Baltimore, MD

Using the “Smurf Transition” to Study Leaky Gut in a Fruit Fly Model
Gregory Shenk, Ph.D., Academy of Aerospace and Engineering, Hartford, CT 
MentorKamal M. Khanna, Ph.D., University of Connecticut Health Center, Farmington, CT

Vaccines and Herd Immunity
Michele Witkowski, Edison High School, Edison, NJ
Mentor: Lisa K. Denzin, Ph.D., Child Health Institute of NJ/Rutgers University, New Brunswick, NJ

Acting Out the Immune Response | Acting Props | Teaching Slides
Catherine Dollard, Northampton High School, Northampton, MA
Mentor: Clinton B. Mathias, Ph.D., Western New England University, Springfield, MA

Chronic Inflammation: The Dark Side of the Inflammatory Process | Teaching Slides
Lori Fretta, Otter Valley Union High School, Brandon, VT
Mentor: Karen A. Fortner, Ph.D., University of Vermont College of Medicine, Burlington, VT

Primer on Immunology Using Dengue Fever as a Real World Application. Extension: Detection of the Prevalence of Lyme Disease in Local Canine Populations
Beth R. Krauss, Manlius Pebble Hill School, DeWitt, NY
Mentor: Gary Winslow, Ph.D., Upstate Medical University, Syracuse, NY

The Basics of Immunology Through Case Studies
Amy Loewen, Hinkley High School, Aurora CO
Mentor: Ronald J. Harbeck, Ph.D., National Jewish Health Advanced Diagnostic Labs, Denver, CO

A Bioinformatics Approach to Systemic Lupus Erythematosus and Autoimmunity
John Siefert, Conrad Weiser Area School District, Robesonia, PA
Mentor: Angelika Antoni, Ph.D., Kutztown University, Kutztown, PA

An Investigation of Light and its Uses in Analysis of the Immunological State
Kindra M. Zuberbuehler, Wake County Public School System, Apex, NC
Mentor: Richard Lee Reinhardt, Ph.D., Duke University Medical Center, Durham, NC

Cancer Cell Technology and Immunology Principles
Robert Aguilar, Western Reserve Academy, Hudson, OH
Mentor: Vincent K. Tuohy, Ph.D., Cleveland Clinic, Cleveland, OH

How can high school students combine computational biology tools with a laboratory model to analyze changes in the human gut microbiome? | Teaching Slides
Andrea Cobb, Ph.D., Thomas Jefferson High School for Science and Technology, Alexandria, VA
Mentor: Patrick M. Gillevet, Ph.D., George Mason University, Manassas, VA

Sounding the Alarm: Studying the Role of Signal Cascades in the Immune System | Teaching Slides
Mark Trice, Frederick High School, Frederick, MD
Mentor: David A. Rozak, Ph.D., The United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD

Investigating the Immune Response of D. rerio Using Keyhole Limpet Hemocyanin
Matthew S. Young, A&M Consolidated High School, College Station, TX 
Mentor: Michael F. Criscitiello, Ph.D., Texas A&M University, College Station, TX

B cell modeling of cell communication and signal transduction pathways: How can students visualize cellular discussions?
Heidi M. Anderson, Paul Laurence Dunbar High School, Lexington, KY
Mentor: Subbarao Bondada, Ph.D., University of Kentucky, Lexington, KY

Exploring the link between regulatory T cells and tumor growth: A lesson in the immune system and cancer | Teaching Slides
Judy J. Birschbach, West Bend East High, West Bend, WI
Mentor: Douglas Steeber, Ph.D., University of Wisconsin-Milwaukee, Milwaukee, WI

CD4+ T-cell differentiation: Using computer modeling to explore the management of the adaptive immune response to inflammation | Supplemental Program Files (NetLogo format - for free NetLogo download, click here.)
Stephen M. Biscotte, Cave Spring High School, Roanoke, VA
Mentor: Josep Bassaganya-Riera, Ph.D., Virginia Polytechnic Institute and State University, Blacksburg, VA

Bacteria, Viruses, and Fungi, Oh My!
Lesli Horowitz, Kearny School of International Business (SDUSD), San Diego, CA
Mentor: Nicholas Gascoigne, Ph.D., The Scripps Research Institute, La Jolla, CA

Use of Immunology Techniques in Crime Scene Analysis by Forensic Scientists | Teaching Slides
Nichole Kellerman, Walter Johnson High School, Bethesda, MD
Mentor: Pamela Schwartzberg, M.D., Ph.D., National Human Genome Research Institute, NIH, Bethesda, MD

Gut Punched: The Role of Gut Microbiota in Inflammatory Disease
Retha R. Prescod, Atlantic Community High School, Delray Beach, FL
Mentor: Zhibin Chen, M.D., Ph.D., University of Miami Miller School of Medicine, Miami, FL

Macrophage profiling of challenged, splenectomized mice: An advanced, secondary curriculum unit on cancer immunology
Jared M. Rashford, Ph.D., Winchester Thurston School, Pittsburgh, PA
Mentor: Kyle McKenna, Ph.D., University of Pittsburgh, Pittsburgh, PA

Macrophage Morphological Changes Due to iNOS Activation by LPS and Its Implication in Chronic Asthma | Teaching Slides
Amanda Smith, Union City High School, Union City, NJ
Mentor:Debra Laskin, Ph.D., Rutgers University, Piscataway, NJ


Where Will Our Next Antibiotic Come From? Investigating the Effects of Plant Extracts on the Growth of E. coli | Teaching Slides
Lori Herrington, Chaparral High School, Temecula, CA
Mentor: Luc Teyton, M.D., Ph.D., The Scripps Research Institute, La Jolla, CA

How does infection spread? The Mechanisms of Immunity: An Introduction to Cancer and Infectious Diseases
Lyndonia L. Pascal, Palm Beach Lakes Community High School, West Palm Beach, FL
Mentor: Zhibin Chen, M.D., Ph.D., University of Miami Miller School of Medicine, Miami, FL

Using the Immune System as a Model for Studying Cell Communication: Toll-like Receptor 2 (TLR2) Polymorphisms, Signaling Function, and Human Disease
Hadiya Woodham, Ph.D., The Park School of Baltimore, Baltimore, MD
Mentor: Andrei Medvedev, Ph.D., University of Maryland School of Medicine, Baltimore, MD

Using Differentiated Instruction to Teach Immunological Concepts to a Diverse Group of Learners
Victor Rodriguez, Southwest High School, San Diego, CA
Mentor: Wendy Havran, Ph.D., The Scripps Research Institute, La Jolla, CA

A Forensic Analysis of Food Poisoning using a Dip-stick Immunoassay
John Goudie, Ed.D., Kalamazoo Area Math and Science Center, Kalamazoo, MI
Mentor: Terecita D. Yule, Ph.D., Pfizer, Inc., Kalamazoo, MI

There's No Time to Teach That: Integrating the Immune System, Autoimmunity, Literacy, and Research into an Over-Crowded Curriculum
Jon Pazol, West Leyden High School, Northlake, IL
Mentor: Stephen D. Miller, Ph.D., Northwestern University Feinberg School of Medicine, Chicago, IL

Lymphoma Resulting From β-Catenin Stabilization are Sensitive to mTOR Inhibition: A Unit on Cancer and the Immune System
Oanh Lo, Marble Hill School for International Studies, Bronx NY
Mentor: Fotini Gounari, Ph.D., The University of Chicago, Chicago, IL

Researching Type I Diabetes
Peter Judson, The Sacred Heart School of Montreal, Montreal, Quebec
Mentor: Ciriaco Piccirillo, Ph.D., Department of Microbiology and Immunology, McGill University Health Center, Montreal, Quebec, Canada

Case Study Which Investigates the Role Environmental Toxins Play in Flu Infection
Elizabeth A. Begy, Geneseo Central School, Geneseo, NY
Mentor: B. Paige Lawrence. Ph.D., University of Rochester School of Medicine and Dentistry, Rochester, NY

Killer Proteins! A Bactericidal Assay to Study the Role of Complement in Killing Bacteria
John F. Long, Dallas Independent School District, Dallas, TX
Mentor: David Farrar, Ph.D., Department of Immunology, UT Southwestern Medical Center, Dallas, TX

Hiding in Plain Site: The Immune System, Tuberculosis, and Antibiotic Resistance
Mark E. Stephansky, Whitman-Hanson Regional High School, Whitman, MA
Mentor: William Cruikshank, Ph.D., Pulmonary Center, Boston University Medical School, Boston, MA

The PTPN22 Gene and It's Role in Familia Autoimmune Disorders
Diane Lee, Magruder High School, Rockville, MD
Mentor: Brian A. Cobb, Ph.D., Case Western Reserve University School of Medicine, Cleveland, OH

From Horses to High School; Bringing Pigeon Fever into the Classroom
Mary Haus, Los Osos High School, Rancho Cucamonga, CA
Mentor: Roberta R. Pollock, Ph.D., Department of Biology, Occidental College, Los Angeles, CA

Exploring Stem Cells: the Role of Stem Cells in Immune System Function
Monica Thoune, Michigan Health Academy, Detroit, MI
Mentor: Mariana J. Kaplan, Ph.D., University of Michigan Medical School, Ann Arbor, MI

Indirect, Competitive Enzyme-Linked Immunosorbent Assay Determination of Secretory Immunoglobulin A Levels in Saliva
David Mwangi, East Orange High School, East Orange, NJ
Mentor: Patricia Fitzgerald-Bocarsly, Ph.D., UMDNJ – New Jersey Medical School, Newark, NJ

Using a Case Study that Focuses on Virus Replication and the Body's Primary Response to the Infection and Subsequent Evaluation of Issues in Epidemiology
Kevin Jarigese, West Mesa High School, Albuquerque, NM
Mentor: Carolyn Mold, Ph.D., Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM

IMMUNOPOLY©, Game for Your/Child's/Families' Life
Kevin Jarigese, West Mesa High School, Albuquerque, NM
Mentor: Carolyn Mold, Ph.D., Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM

Doctor YOU: Applying Immunological Methodology to Diagnosis
Rita English, John F. Kennedy Memorial High School, Iselin, NJ
Mentor: Debra Laskin, Ph.D., Department of Pharmacology/Toxicology, Rutgers University, Piscataway, NJ

Interactive Computer Simulations for Teaching Tumor Immunology
Nels Dokken, John F. Kennedy High School, South Bloomington, MN
Mentor: Chris Pennell, Ph.D., Department of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN

Understanding Lupus and Auto-Immune Diseases
Laurie E. Asermily, Seneca Falls Central School, Seneca Falls, NY
Mentor: Jennifer Anolik, M.D., Ph.D., Univ. of Rochester Medical Center, Rochester, NY

Cell Communication
Teresa R. Burke, Westford Academy, Westford, MA
Mentor: William Walker Cruikshank, Ph.D., Boston Univ. School of Medicine, Boston, MA

Are You What You Eat? Detection of Body Fluid Contamination of Food
Emily K. Faulconer, Lakeland High School, Suffolk City Public Schools, Suffolk, VA
Mentor: Robert Eugene Ratzlaff, Ph.D., Old Dominion Univ., Norfolk, VA

"Can You Hear Me Now?" Cell Communication
Dawn M. Martell, Wilmington High School, Wilmington, MA
Mentor: William Walker Cruikshank, Ph.D., Boston Univ. School of Medicine, Boston, MA

The Immune System: Defenders of our Health – Who are "those guys anyways"?
Elizabeth Withum, A.W. Coolidge Middle School, Reading, MA
Mentor: Rachel M. McLoughlin, Ph.D., Brigham & Women's Hospital, Harvard Medical School, Boston, MA


Using Immunology as a Model to Teach Cell Communication
Ann Brokaw, Rocky River High School, Rocky River, OH
Mentor: Brian A. Cobb, Ph.D., Case Western Reserve Univ., Cleveland, OH

CSI Ann Arbor: A Middle School look at Polymerase Chain Reaction or PCR Technology
Philip Lundy, Brighton Area Schools, Brighton, MI
Mentor: Nicholas W. Lukacs, Ph.D., Univ. of Michigan, Ann Arbor, MI

Our Body's Response to Infectious Diseases
Debra Paul, F.H. Tuttle Middle School, South Burlington, VT
Mentor: Ralph C. Budd, M.D., Univ. of Vermont College of Medicine, Burlington, VT

T and B Cell Pathways: An Introduction to the Immune System
Mark Paul, Essex High School, Essex Junction, VT
Mentor: Ralph C. Budd, M.D., Univ. of Vermont College of Medicine, Burlington, VT

Is That My Blood? ABO Blood Types
Felicia A. Benson, Osborn High School, Detroit, MI
Mentor: Yi-Chi M. Kong, Ph.D., Wayne State University School of Medicine, Detroit, MI

Eating for Health: A Look at How Diet Can Effect the Immune System
Amanda Dice, Baltimore Talent Development High School, Baltimore, MD
Mentor: Jan L. Powell, Ph.D., University of Maryland School of Medicine, Baltimore, MD

The Basics of Immunology and the Ethics of Animal Research
Claire L. Hypolite, Edison High School, Minneapolis, MN
Mentor: Kristin A. Hogquist, Ph.D., University of Minnesota, Minneapolis, MN

Observation of Phagocytosis and Respiratory Burst in Neutrophils
Marjorie Maxey, Western Albermarle High School, Crozet, VA
Mentor: Robert G. Sawyer, M.D., University of Virginia, Charlottesville, VA

The Bull's Eye of the Immune System
Tamica A. Stubbs, E. E. Waddell High School, Charlotte, NC
Mentor: Juan Anguita, Ph.D., University of North Carolina, Charlotte, NC

Bringing Immune Cell Migration into the High School Classroom
Elizabeth Zdrojewski, West Allis West Milwaukee School, West Allis, WI
Mentor: Douglas A. Steeber, Ph.D., University of Wisconsin, Milwaukee, WI

Identification of E-coli at Various Dilutions Using the ELISA Test
Alice Apostolou, Tahanto Regional High School, MA
Mentor: Frank Gibson, Ph.D., Boston University Medical School

Who Compromised My Immune System?
Beverly Feig and Nicole Veltre, Digital Harbor High School, Baltimore, MD
Mentor: Jan L. Powell, Ph.D., University Maryland Medical School

ELISA for Your Biology Classes: Using Mouse Serum OVA-specific IgE to Illustrate the Inflammatory Response as it Occurs in Asthmatics. An easily adapted protocol for all types of daily schedules
Susan P. Mooney and Richard Willets, Haverhill High School, Haverhill, MA
Mentors: Dennis L. Kasper, Ph.D. and Greg Priebe, M.D., Harvard University Medical School

Understanding Immunity by Tracing Thymocyte Development
Dan O'Connell, St. Andrew's School, Middletown, DE
Mentor: Jennifer A. Punt, V.M.D., Ph.D., Haverford College, Philadelphia, PA

Using a Modified ELISA Assay to Demonstrate the Transmission of a Simulated Disease and the Subsequent Identification of the Bacterial Agent
Kara Jon Christesen and Aurora Merry, Salem High School, Salem, NH
Mentor: Andrew B. Onderdonk, Ph.D., Harvard University, and Arthur O. Tzianabos, Ph.D., Harvard Medical School

An Asthma Vaccine! Is it Possible?
Gloria J. Gilliam, North High School, Omaha, NE
Mentor: Devendra K. Agrawal, Ph.D., Creighton University

Scientific Methods Now and Then: A Historical Perspective
Tammy Morgan, Lake Placid High School, Lake Placid, NY
Mentor: Peter C. Sayles, Ph.D., Trudeau Institute

Biotechnology WebQuest
Amy J. Parent, Tupper Lake High School, Tupper Lake, NY
Mentor: Richard W. Dutton, Ph.D., Trudeau Institute

Laboratory Activities to Enhance the Study of Whole Blood Components and their Role in the Immune Response
Thomas E. Schmit, Hamilton High School, Hamilton, MT
Mentor: Frank R. DeLeo, Ph.D., NIAID, NIH, Hamilton, MT

How do Immunologists Study Disease? And The Immune Response to Friend Virus Disease
James F. Striebel, Corvallis High School, Corvallis, MT
Mentor: Kim J. Hasenkrug, Ph.D., NIAID, NIH, Hamilton, MT

Genetic Engineering: A Journey Into DNA Science
LeeAnn Vaughan, North High School, Omaha, NE
Mentor: Kristen M. Drescher, Ph.D., Creighton University

Acting Out the Immune Response
Lindsay E. Porter, Pollard Middle School, Needham, MA
Mentor: Rao H. Prabhala, Ph.D., Dana-Farber Cancer Institute

Armed and Dangerous: The Activation of Killer T-Cells Student Activity
Thomas J. Geelan, City Honors School, Buffalo, NY
Mentor: Elizabeth Repasky, Ph.D., Roswell Park Cancer Institute

Standing on Guard for You
L. Dee Eller, Coupeville High School, Coupeville, WA
Mentor: Philip F. Mixter, Ph.D., Washington State University

Understanding the Components of Innate and Adaptive Immunity
Dean Johnson, City Honors School, Buffalo, NY

You Are the Doctor! Part 1 and Assessment
Beth-Ann M. Shepley, Avon Middle-High School, Avon, MA